PMID: 6169850Oct 1, 1981Paper

Disseminated seminoma: re-evaluation of treatment protocols

The Journal of Urology
W L MendenhallJ P Donohue

Abstract

Radiotherapy provides a high cure rate for patients with stages I and II seminoma but the results for those with stage III disease have been disappointing. We report on 19 patients with high stage seminoma who have been treated with platinum, vinblastine and bleomycin (14 patients) or platinum, vinblastine, bleomycin and doxorubicin hydrochloride (5 patients). Of the 19 patients 12 (63 per cent) had complete remission of the disease and the remaining 7 had partial remission. To date, 11 patients (58 per cent) remain free of disease. Of the 6 patients with no prior irradiation 5 achieved complete remission, while the 1 failure had massive hepatic metastases. The median followup was 19 months (range 12 to 37 months). These results parallel that achieved with the same chemotherapy regimen in patients with stage III nonseminomatous testicular cancer.

References

Dec 1, 1978·The Journal of Urology·N JavadpourS M Bergman
Apr 1, 1979·The Journal of Urology·R B SmithD G Skinner
Jan 1, 1977·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·W F WhitmoreR Golbey
Jan 1, 1973·Annals of Internal Medicine·G D BraunsteinG T Ross
Jul 1, 1974·The Journal of Urology·D J HigbyJ F Holland
Mar 1, 1968·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J G MaierB T Mittemeyer
Nov 1, 1966·The Journal of Urology·A R Mackenzie
Oct 1, 1980·The Journal of Urology·P H LangeJ M Streitz
Apr 24, 1958·Annals of the New York Academy of Sciences·N BLOKHINN MERKULOVA

❮ Previous
Next ❯

Citations

Jun 1, 1984·Cancer·D Vugrin, W F Whitmore
May 1, 1984·Cancer·A G CockburnW F Whitmore
Sep 1, 1990·The Journal of Urology·S R SmalleyR L Richardson
Apr 1, 1983·The Journal of Urology·E D CrawfordJ B deKernion
Aug 15, 1987·Cancer·G S LedermanC N Coleman
May 1, 1983·Urology·N GreenZ Petrovich
Oct 1, 1985·International Journal of Radiation Oncology, Biology, Physics·B D Willan, D G McGowan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.