Disseminated tumor cells from the bone marrow of patients with nonmetastatic primary breast cancer are predictive of locoregional relapse

Annals of Oncology : Official Journal of the European Society for Medical Oncology
Andreas HartkopfF-A Taran

Abstract

Disseminated tumor cells (DTCs) are detectable in the bone marrow (BM) of patients with primary breast cancer (PBC) and predictive of an impaired prognosis. This large trial aimed to analyze the impact of DTC detection on locoregional relapse (LR). Patients with nonmetastatic PBC were eligible for this analysis. BM aspiration (BMA1) was carried out during primary surgery and DTCs were detected by using immunocytochemistry (A45-B/B3 antibody against pancytokeratin) and morphological criteria. At the time of LR, a subgroup of patients with nonmetastatic and operable LR received a secondary BM aspiration (BMA2). A total of 3072 patients were included into the analysis. Of these, 732 (24%) presented with DTCs at BMA1. One hundred thirty-nine patients experienced LR and 48 of these (35%) were initially DTC positive. DTC detection was significantly associated with an increased risk of LR in univariate (P = 0.002) and multivariate analysis (P = 0.009) with a hazard ratio of 1.65 (95% confidence interval 1.13-2.40). Of the patients with LR, 55 patients were available for BMA2 and 17 of these (32%) were DTC positive. DTC detection at the time of LR was indicative of impaired overall survival (univariate analysis, P = 0.037). DTC detecti...Continue Reading

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Citations

Jul 25, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A AlkanG Utkan
Jul 26, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A D HartkopfF-A Taran
Sep 27, 2018·Journal of Cellular and Molecular Medicine·Buqing Sai, Juanjuan Xiang
Mar 5, 2019·JCI Insight·Hideyuki ShimizuKeiichi I Nakayama
Feb 11, 2020·Breast Cancer Research and Treatment·Tilman D RachnerAnn-Kathrin Bittner
Mar 16, 2019·Current Treatment Options in Oncology·Hadar Goldvaser, Eitan Amir
May 20, 2020·Therapeutic Advances in Medical Oncology·Galatea KallergiSabine Kasimir-Bauer

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