Disseminating Melanoma Cells Surf on Calcium Waves

Molecular & Cellular Oncology
Jianwei SunShengyu Yang

Abstract

Dysregulated calcium signaling has been increasingly implicated in tumor dissemination and progression. In a recent study we investigated the mechanism underlying calcium-mediated melanoma invasion and metastasis, and discovered that hyperactive Ca(2+) oscillation in melanoma cells promoted invasion and metastasis through promoting invadopodium formation and extracellular matrix remodeling.

References

Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Dec 18, 2007·Cell·David E Clapham
Feb 18, 2011·Nature Reviews. Cancer·Alexander NürnbergRobert Grosse
Jul 23, 2011·Nature Reviews. Cancer·Natalia PrevarskayaYaroslav Shuba

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Citations

Mar 13, 2016·Medical Hypotheses·Leo ČabrijanJasna Lipozenčić
Mar 7, 2020·The American Journal of Pathology·Amel SalhiIman Osman
Dec 3, 2021·Biochemical Society Transactions·Fujian LuShengyu Yang

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Methods Mentioned

BETA
xenograft

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