Dissemination, divergence and establishment of H7N9 influenza viruses in China

Nature
Tommy Tsan-Yuk LamHuachen Zhu

Abstract

Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens. Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 (refs 3-7). It is unclear how the H7N9 virus re-emerged and how it will develop further; potentially it may become a long-term threat to public health. Here we show that H7N9 viruses have spread from eastern to southern China and become persistent in chickens, which has led to the establishment of multiple regionally distinct lineages with different reassortant genotypes. Repeated introductions of viruses from Zhejiang to other provinces and the presence of H7N9 viruses at live poultry markets have fuelled the recurrence of human infections. This rapid expansion of the geographical distribution and genetic diversity of the H7N9 viruses poses a direct challenge to current disease control systems. Our results also suggest that H7N9 viruses have become enzootic in China and may spread beyond the region, following the pattern previously observed with H5N1 and H9N2 influenza viruses.

References

Sep 24, 2005·Molecular Biology and Evolution·Beth ShapiroAlexei J Drummond
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·G GabrielJ Stech
May 11, 2006·PLoS Biology·Alexei J DrummondAndrew Rambaut
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Apr 15, 2008·Molecular Biology and Evolution·Vladimir N MininMarc A Suchard
Apr 21, 2009·Methods in Molecular Biology·Stéphane GuindonOlivier Gascuel
Sep 26, 2009·PLoS Computational Biology·Philippe LemeyMarc A Suchard
Jul 31, 2010·Bioinformatics·Wayne DelportSergei L Kosakovsky Pond
Apr 4, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tommy Tsan-Yuk LamFrederick Chi-Ching Leung
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu
Jun 6, 2013·Virus Research·Yi Guan, Gavin J D Smith
Sep 24, 2013·Cell Host & Microbe·Aiping WuTaijiao Jiang
Nov 2, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E ChenH Yu
Feb 28, 2014·Journal of Virology·Mary J Pantin-JackwoodDavid L Suarez
Jul 6, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·D WangY Shu

❮ Previous
Next ❯

Citations

Dec 15, 2015·The Lancet Infectious Diseases·J S Malik PeirisGabriel M Leung
Nov 26, 2015·Advanced Healthcare Materials·Jun Ho SonLuke P Lee
Dec 23, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pei-Yu HuangYi Guan
Feb 29, 2016·Current Opinion in Virology·Huachen ZhuYi Guan
Jan 23, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jørgen de JongeLarisa Rudenko
Dec 23, 2015·Emerging Infectious Diseases·Danuta M SkowronskiYan Li
Jul 25, 2015·Epidemiology and Infection·W D TannerA V Gundlapalli
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jemma L GeogheganEdward C Holmes
Apr 12, 2016·Frontiers in Microbiology·Malak M AlameHassan Zaraket
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Zhaoqin ZhuYunwen Hu
Jun 24, 2015·Science China. Life Sciences·Mi LiuTaiJiao Jiang
Apr 2, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hong Kai Lee, Julian W Tang
Jun 23, 2016·Emerging Infectious Diseases·Yong-Yi ShenMing Liao
May 19, 2016·Emerging Infectious Diseases·Peng WuBenjamin J Cowling
Jun 29, 2016·ELife·Ignacio MenaAdolfo García-Sastre
May 25, 2016·Annual Review of Genomics and Human Genetics·Tommy T-Y LamEdward C Holmes
Nov 1, 2016·Nature Nanotechnology·Seok-Joon KwonRobert J Linhardt
Nov 17, 2015·IEEE Transactions on Cybernetics·Jian-Bo WangXiang Li
Jan 20, 2016·PloS One·Martha I NelsonDaniel G Bausch
Jan 14, 2017·Scientific Reports·Ilseob LeeMan-Seong Park
Apr 5, 2017·PloS One·Chau Minh BuiSahotra Sarkar
Aug 8, 2017·International Journal of Molecular Sciences·Wenhan ShaoJi-Long Chen
Feb 14, 2018·The Journal of Infectious Diseases·Dan XiangYongyi Shen
Apr 6, 2018·Emerging Infectious Diseases·Qiqi YangHuaiyu Tian
Oct 27, 2017·Open Biology·Jemma L Geoghegan, Edward C Holmes

❮ Previous
Next ❯

Related Concepts