Dissemination of bla OXA-370 gene among several Enterobacteriaceae species in Brazil

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Cibele M MagagninAlexandre P Zavascki

Abstract

OXA-370 is a recently described OXA-48 variant that has only been described in a few Enterobacter spp. and Klebsiella pneumoniae isolates. The purpose of this study is to assess the prevalence of OXA-370-producing isolates in carbapenem-nonsusceptible Enterobacteriaceae recovered from 28 hospitals from Brazil. Real-time PCR was used to determine the presence of bla NDM-1, bla KPC-2, bla VIM-type, bla GES-type, bla OXA-48-like, and bla IMP-type genes. A total of 4,451 Enterobacteriaceae were screened. The gene bla OXA-48-like was detected in 74 (2.5%) isolates, mostly of Enterobacter spp. (44.6% E. cloacae and 2.7% E. aerogenes) and Klebsiella spp. (31.1% K. pneumoniae and 6.7% K. oxytoca), followed by Escherichia coli, (6.7%), Morganella morganii, (2.7%), Citrobacter freundii (1.3%), Proteus mirabilis (1.3%), Providencia stuartii (1.3%), and Serratia spp. (1.3%). These isolates were from five hospitals, 67 (90.5%) from the hospital where the bla OXA-370 was first described. Sequencing of bla OXA-48-like was performed in 52 isolates, including E. cloacae, E. aerogenes, K. pneumoniae, K. oxytoca, E. coli, and C. freundii; all presenting 100% identity with bla OXA-370. PFGE revealed the presence of distinct clones among K. pneumon...Continue Reading

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Citations

Oct 11, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Assia MairiAziz Touati
Aug 27, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Lisiane Rech PancottoAfonso Luis Barth
Feb 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Roberto VivasSona Jain
Jul 21, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Franciéli P RozalesAfonso Luis Barth
Nov 15, 2019·Clinical Microbiology Reviews·Johann D D PitoutYasufumi Matsumura
Aug 22, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Cibele M MagagninJorge L M Sampaio
Jul 19, 2020·Antibiotics·Andressa Liberal SantosLilian Carla Carneiro
Jul 5, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Priscila Lamb WinkAfonso Luis Barth
Jan 29, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Otávio A LovisonAndreza F Martins
Nov 19, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Sivoneide Maria da SilvaMaria Betânia Melo de Oliveira

Methods Mentioned

BETA
PCR
electrophoresis

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