Dissociable components of spatial neglect associated with frontal and parietal lesions

Neuropsychologia
Arnaud SajP Vuilleumier

Abstract

Spatial neglect is a complex neuropsychological disorder, in which patients fail to detect and respond to contralesional stimuli. Recent studies suggest that these symptoms may reflect a combination of different component deficits, associated with different lesion substrates. Thus, damage to right lateral prefrontal and inferior parietal regions produce different degrees of left neglect on cancellation and line bisection tasks, respectively. Here we tested for dissociable behaviors across two tasks designed to assess distinct cognitive processes possibly mediating such components, in 14 patients with right focal lesion in either the frontal or parietal lobe. In the "distractor filtering" task, patients had to respond to a visual target presented centrally, with or without a lateralized distractor. Only frontal-lesioned patients showed a marked slowing of reaction times when a central target appeared with a simultaneous right distractor (compared to center and left distractor). In the "spatial coding" task, patients had to detect a target among successive visual stimuli presented horizontally with three sequence conditions (regular/predictive or irregular/non-predictive). Only parietal-lesioned patients were unable to benefit fr...Continue Reading

References

Feb 1, 1979·Annals of Neurology·K M Heilman, E Valenstein
Nov 1, 1992·Archives of Neurology·J BinderJ P Mohr
Apr 11, 1991·Nature·P W Halligan, J C Marshall
Aug 1, 1990·Journal of Neurophysiology·M E Goldberg, C J Bruce
Apr 1, 1988·Canadian Journal of Physiology and Pharmacology·R A Andersen, D Zipser
Jul 1, 1970·Neuropsychologia·G Gainotti, C Tiacci
Jan 1, 1980·Journal of Neurophysiology·L E Mays, D L Sparks
Jan 1, 1980·Neuropsychologia·A R DamasioH C Chui
Sep 1, 1995·Cerebral Cortex·C L ColbyM E Goldberg
Mar 1, 1996·Brain Research. Cognitive Brain Research·A X EllisR H Logie
Jun 1, 1997·Neuropsychologia·M Husain, C Kennard
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M M Mesulam
Aug 10, 2000·Journal of Cognitive Neuroscience·J Driver, A Pouget
Aug 10, 2000·Experimental Brain Research·M Petrides
Feb 13, 2001·Neuropsychologia·E WojciulikJ Driver
Sep 8, 2001·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·J LupiáñezS P Tipper
Sep 25, 2001·Behavioural Neurology·Chris Rorden, Matthew Brett
Feb 15, 2002·Brain : a Journal of Neurology·Hans Otto KarnathChris Rorden
Feb 22, 2002·Neuroscience and Biobehavioral Reviews·Fabienne Collette, Martial Van der Linden
Apr 19, 2002·Brain : a Journal of Neurology·A E HillisE J Metter
Jun 25, 2003·Brain : a Journal of Neurology·Dominic J MortMasud Husain
Oct 31, 2003·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Bradley R PostleMark D'Esposito
Nov 20, 2003·Neuroreport·Fabrizio Doricchi, Francesco Tomaiuolo
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·Laure Pisella, Jason B Mattingley
Oct 28, 2004·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Edoardo BisiachA David Milner
Oct 28, 2004·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Paresh MalhotraMasud Husain
Oct 1, 2005·Science·Michel Thiebaut de SchottenPaolo Bartolomeo
Oct 20, 2005·Nature Neuroscience·Maurizio CorbettaAyelet Sapir
Oct 26, 2005·Neuropsychologia·Maurizio CorbettaGordon L Shulman
Nov 11, 2005·Current Opinion in Neurology·A David Milner, Robert D McIntosh
Nov 23, 2005·Neuropsychologia·James Danckert, Susanne Ferber
Jul 27, 2007·Journal of Cognitive Neuroscience·Patrik VuilleumierJon Driver
Sep 6, 2007·Neuropsychology Review·María Beatriz Jurado, Mónica Rosselli
Nov 10, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·M UrbanskiP Bartolomeo
Jul 8, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Fabrizio DoricchiPaolo Bartolomeo
Oct 14, 2008·Current Biology : CB·Patrik VuilleumierJon Driver
Jan 27, 2009·Cerebral Cortex·Hans-Otto KarnathLuca F Ticini
Dec 24, 2009·Brain : a Journal of Neurology·Vincent VerdonPatrik Vuilleumier

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Citations

Dec 12, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kilian FröhlichKlemens Winder
Oct 27, 2018·The Clinical Neuropsychologist·Jordan Pierce, Arnaud Saj
Jun 8, 2019·Brain Research·Daniel M StoutVictoria B Risbrough
Aug 4, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Antonia F Ten BrinkStefan Van der Stigchel
Jun 10, 2019·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Arnaud SajPatrik Vuilleumier
Jul 18, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Joris A ElshoutStefan Van der Stigchel
Dec 16, 2018·Annals of Physical and Rehabilitation Medicine·Jordan PierceArnaud Saj

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