PMID: 9189263Jun 1, 1997Paper

Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning

Behavioral Neuroscience
M Good, R C Honey

Abstract

Rats received excitotoxic lesions of different subsystems within the hippocampal system--either the hippocampus proper (cornu ammonis and dentate gyrus; hippocampal lesions) or the entorhinal cortex-subicular region (entorhinal lesions). Subsequently, their activity in an operant chamber was monitored both before and after footshock had been delivered (Experiment 1). Rats with hippocampal lesions showed enhanced activity before the delivery of footshock and reduced freezing after the delivery of shock. Rats with entorhinal lesions showed control levels of activity before the delivery of footshock and control levels of freezing after the delivery of footshock. Both types of lesion impaired spatial learning in a water maze (Experiment 2). These results suggest that the deficits arising from damage to the hippocampal system in contextual and spatial learning have different origins.

Citations

May 5, 1999·Hippocampus·P C HollandM Gallagher
Mar 23, 2001·Hippocampus·S G AnagnostarasM S Fanselow
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Apr 13, 2006·Journal of Autism and Developmental Disorders·George C WagnerAlycia K Halladay
Aug 12, 2008·Molecular Neurobiology·Justin W Kenney, Thomas J Gould
Jun 3, 2004·Neuroscience and Biobehavioral Reviews·Kathryn J JefferySubhojit Chakraborty
May 5, 2004·Epilepsy & Behavior : E&B·Mohamad A MikatiCarl E Stafstrom
Dec 23, 1998·Biological Psychiatry·J LeDoux
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Gernot RiedelEuan M Macphail
May 19, 2000·Neuroscience and Biobehavioral Reviews·M Colombo, N Broadbent
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L E KalynchukE G Marchant
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Feb 13, 2001·Behavioural Brain Research·K H ChanT L Davidson
Nov 24, 2001·Behavioural Brain Research·A L TracyT L Davidson
Mar 19, 2003·Behavioural Brain Research·D M BannermanJ N P Rawlins
May 10, 2000·Behavioural Brain Research·M S Fanselow
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Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Riedel, J Micheau
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Nov 21, 2000·Behavioral Neuroscience·D J BucciR D Burwell
Apr 29, 2004·Behavioral Neuroscience·V J MarshallR C Honey
Oct 28, 2004·Behavioral Neuroscience·D M BannermanJ N P Rawlins
Nov 23, 2005·Behavioral Neuroscience·Bill P GodsilMichael S Fanselow
Apr 25, 2007·The Quarterly Journal of Experimental Psychology : QJEP·R C HoneyM Good

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