Dissociable Frontostriatal Connectivity: Mechanism and Predictor of the Clinical Efficacy of Capsulotomy in Obsessive-Compulsive Disorder

Biological Psychiatry
Dazhi YinBomin Sun

Abstract

Little is known about the neural mechanism and response variability underlying neurosurgical interventions for intractable obsessive-compulsive disorder (OCD). Of 81 OCD patients screened for capsulotomy identified in our institutional database, 36 patients with clinical assessment before and after capsulotomy and imaging data (9 of 36 patients without postoperative imaging data used as an independent test group), and 29 healthy control subjects were retrospectively recruited. Twenty of 36 patients (56%) responded to the lesion procedure (determined as a ≥35% reduction in Yale-Brown Obsessive Compulsive Scale [Y-BOCS] score). Seed-based (i.e., ventral and dorsal caudate, medial dorsal thalamus, and ventral and dorsal putamen) resting-state functional connectivity was used to examine alterations in frontostriatal circuitry after capsulotomy. The Y-BOCS score significantly decreased (p < .001) after capsulotomy in OCD patients. Functional connectivity between the ventral striatum/nucleus accumbens and the dorsal anterior cingulate cortex was reduced (p < .05, corrected) after the surgical procedure. Moreover, change in connectivity significantly correlated with alteration in Y-BOCS score (r = .41, p = .033). In addition, preopera...Continue Reading

Citations

Jul 10, 2019·Movement Disorders Clinical Practice·Chencheng ZhangLi Dianyou
Mar 3, 2020·Frontiers in Psychiatry·Chencheng ZhangBomin Sun
Mar 1, 2019·The Journal of Clinical Endocrinology and Metabolism·Fang FangYu-Fan Wang
Jan 2, 2021·The American Journal of Psychiatry·Wayne K GoodmanSameer A Sheth
Jul 13, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Qian LvZheng Wang
Dec 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Liang FengLingjing Jin
Jan 20, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Chencheng ZhangValerie Voon
Jan 26, 2021·Acta Psychiatrica Scandinavica·Sarah Babette HagemanDamiaan Denys
Aug 27, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven A Rasmussen, Wayne K Goodman

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