PMID: 9528920Apr 7, 1998Paper

Dissociable long-term cognitive deficits after frontal versus sensorimotor cortical contusions

Journal of Neurotrauma
M D LindnerR L Sutton

Abstract

Cognitive deficits are the most enduring and disabling sequelae of human traumatic brain injury (TBI), but quantifying the magnitude, duration, and pattern of cognitive deficits produced by different types of TBI has received little emphasis in preclinical animal models. The objective of the present study was to use a battery of behavioral tests to determine if different impact sites produce different patterns of behavioral deficits and to determine how long behavioral deficits can be detected after TBI. Prior to surgery, rats were trained to criteria on delayed nonmatching to position, radial arm maze, and rotarod tasks. Rats received sham surgery (controls), midline frontal contusions (frontal TBI, 2.25 m/sec impact), or unilateral sensorimotor cortex contusions (lateral TBI, 3.22 m/sec impact) at 12 months of age and were tested throughout the next 12 months. Cognitive deficits were more robust and more enduring than sensorimotor deficits for both lateral TBI and frontal TBI groups. Lateral TBI rats exhibited transient deficits in the forelimb placing and in the rotarod test of motor/ambulatory function, but cognitive deficits were apparent throughout the 12-month postsurgery period on tests of spatial learning and memory in...Continue Reading

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Citations

Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·F BertrandJ C Cassel
Mar 1, 2006·Journal of Neurotrauma·Asla Pitkänen, Tracy K McIntosh
Aug 23, 2007·Journal of Neurotrauma·Amy K WagnerAmina S Khan
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Corina O BondiAnthony E Kline
Nov 3, 2007·Neurochemistry International·Dan JiNeville N Osborne
Jul 19, 2005·Annals of the New York Academy of Sciences·Donald G Stein
Oct 3, 2008·Journal of Neuroscience Research·Grace Sophia GriesbachFernando Gomez-Pinilla
Sep 3, 2004·Neuroscience and Biobehavioral Reviews·Scott T FujimotoTracy K McIntosh
Sep 22, 2006·Neuroscience Letters·Michael R HoaneJeremy L Pierce
Oct 21, 2016·Journal of Neurotrauma·Cole Vonder Haar, Catharine A Winstanley
Jul 29, 2006·Neurobiology of Aging·Christian FreichelPhilipp J Kahle

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