Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniele CaprioliJeffrey W Dalley

Abstract

We have previously shown that impulsivity in rats is linked to decreased dopamine D2/3 receptor availability in the ventral striatum. In the present study, we investigated, using longitudinal positron emission tomography (PET), the effects of orally administered methylphenidate (MPH), a first-line treatment for attention deficit hyperactivity disorder, on D2/3 receptor availability in the dorsal and ventral striatum and related these changes to impulsivity. Rats were screened for impulsive behavior on a five-choice serial reaction time task. After a baseline PET scan with the D2/3 ligand [(18)F]fallypride, rats received 6 mg/kg MPH, orally, twice each day for 28 d. Rats were then reassessed for impulsivity and underwent a second [(18)F]fallypride PET scan. Before MPH treatment, we found that D2/3 receptor availability was significantly decreased in the left but not the right ventral striatum of high-impulse (HI) rats compared with low-impulse (LI) rats. MPH treatment increased impulsivity in LI rats, and modulated impulsivity and D2/3 receptor availability in the dorsal and ventral striatum of HI rats through inverse relationships with baseline levels of impulsivity and D2/3 receptor availability, respectively. However, we foun...Continue Reading

Citations

Jul 3, 2015·The International Journal of Neuropsychopharmacology·Valerie VoonNeil A Harrison
Mar 24, 2016·Behavioural Processes·Sarah E SniderWarren K Bickel
Apr 20, 2016·Behavioural Brain Research·Alicia IzquierdoAlexandra Stolyarova
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Jan 1, 2020·Neurobiology of Pain·Ana Margarida CunhaHugo Leite-Almeida

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