Dissociable roles for cortical and subcortical structures in memory retrieval and acquisition.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anna S MitchellD Gaffan

Abstract

The relationship between anterograde and retrograde amnesia remains unclear. Previous data from both clinical neuropsychology and monkey lesion studies suggest that damage to discrete subcortical structures leads to a relatively greater degree of anterograde than retrograde amnesia, whereas damage to discrete regions of cortex leads to the opposite pattern of impairments. Nevertheless, damage to the medial diencephalon in humans is associated with both retrograde and anterograde amnesia. In the present study, we sought to reconcile this by assessing retention as well as subsequent relearning and new postoperative learning. Rhesus monkeys learned 300 unique scene discriminations preoperatively, and retention was assessed in a preoperative and postoperative one-trial retrieval test. Combined bilateral subcortical lesions to the magnocellular mediodorsal thalamus and fornix impaired postoperative retention of the preoperatively acquired information. In addition, subsequent relearning and new postoperative learning were also impaired. This contrasts with the effects of a discrete lesion to just one of these structures, after which retention is intact in both cases. Discrete bilateral ablations to the entorhinal cortex impaired rete...Continue Reading

Citations

Mar 8, 2016·Cerebral Cortex·Mark J Buckley, Anna S Mitchell
May 17, 2015·Cerebral Cortex·Philip G F BrowningAnna S Mitchell
May 25, 2011·Neuroscience and Biobehavioral Reviews·Yumiko Watanabe, Shintaro Funahashi
Aug 4, 2015·Seminars in Ultrasound, CT, and MR·Flavius D RaslauJohn L Ulmer
Aug 12, 2014·Neurobiology of Learning and Memory·Nicole J GervaisDave G Mumby
Jul 20, 2018·The European Journal of Neuroscience·Subhojit ChakrabortyAnna S Mitchell
Sep 18, 2018·Brain and Neuroscience Advances·Anna S MitchellAndrew J D Nelson
Apr 2, 2021·NeuroImage·P Christiaan KlinkChristopher I Petkov

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