Dissociable roles for the nucleus accumbens core and shell in regulating set shifting

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stan B FlorescoOrsolya Magyar

Abstract

The ability to behave in a flexible manner is an executive function mediated in part by different regions of the prefrontal cortex. The present study investigated the role of two major efferents of the prefrontal cortex, the nucleus accumbens (NAc) core and shell, in behavioral flexibility using a maze-based strategy set-shifting task. During initial discrimination training, rats learned to use either an egocentric response or a visual-cue discrimination strategy to obtain food reward. During the set shift, animals had to shift from the previously acquired response or visual-cue-based strategy and learn the alternate discrimination. Inactivation of the NAc core, induced by infusion of the GABA agonists baclofen and muscimol, did not impair initial acquisition of either a response or visual-cue discrimination but severely disrupted shifting from one strategy to another. Analysis of the type of errors revealed that impairments in set shifting were not attributable to increased perseveration but to a disruption of the acquisition and maintenance of a new strategy. In contrast, inactivation of the NAc shell did not impair acquisition of either a response or a visual-cue discrimination, or shifting from one strategy to another. Howe...Continue Reading

Citations

Jun 6, 2006·Psychopharmacology·Matthew N HillStan B Floresco
Nov 11, 2009·Psychopharmacology·Katherine E BurnhamTrevor Sharp
Feb 8, 2008·Brain Structure & Function·Gloria E MeredithAnn E Kelley
Nov 20, 2013·Neurobiology of Learning and Memory·Phillip M Baker, Michael E Ragozzino
Apr 20, 2011·Behavioral Neuroscience·Amy C ChessJohn T Green
Nov 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nadia ChaudhriPatricia H Janak
Mar 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Desirae M Haluk, Stan B Floresco
Sep 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stan B Floresco, James D Jentsch
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alessandro GozziMarina Bentivoglio
Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie M BrooksJohn P Bruno
Dec 20, 2007·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Shawn F Smyth, David Q Beversdorf
Sep 18, 2008·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Andrew S PederzolliDavid Q Beversdorf
Apr 9, 2009·PloS One·Aaron J GruberPatricio O'Donnell
Jul 21, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caitlin E PietteAnan Moran
Aug 25, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark R Stefani, Bita Moghaddam
Oct 29, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Holden D BrownMichael E Ragozzino
May 14, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Justin T GassL Judson Chandler
Jan 26, 2011·Cognitive, Affective & Behavioral Neuroscience·Colin M Stopper, Stan B Floresco
Jun 27, 2015·Neuroscience and Biobehavioral Reviews·Simon R O NilssonPeter G Clifton
Dec 18, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laurel S MorrisValerie Voon
May 9, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pablo PandolfoRodrigo A Cunha
Nov 8, 2011·Behavioural Brain Research·Dionisio A AmodeoMichael E Ragozzino
Nov 27, 2010·Pharmacology, Biochemistry, and Behavior·Aaron EttenbergOsnat Ben-Shahar
Aug 4, 2009·Behavioural Brain Research·Anne Marie Brady
Sep 3, 2008·Experimental Neurology·Thibaut SesiaVeerle Visser-Vandewalle
Jun 3, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mark J HuntStefan Kasicki

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