Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception

ELife
Carl J HodgettsK S Graham

Abstract

We tested a novel hypothesis, generated from representational accounts of medial temporal lobe (MTL) function, that the major white matter tracts converging on perirhinal cortex (PrC) and hippocampus (HC) would be differentially involved in face and scene perception, respectively. Diffusion tensor imaging was applied in healthy participants alongside an odd-one-out paradigm sensitive to PrC and HC lesions in animals and humans. Microstructure of inferior longitudinal fasciculus (ILF, connecting occipital and ventro-anterior temporal lobe, including PrC) and fornix (the main HC input/output pathway) correlated with accuracy on odd-one-out judgements involving faces and scenes, respectively. Similarly, blood oxygen level-dependent (BOLD) response in PrC and HC, elicited during oddity judgements, was correlated with face and scene oddity performance, respectively. We also observed associations between ILF and fornix microstructure and category-selective BOLD response in PrC and HC, respectively. These striking three-way associations highlight functionally dissociable, structurally instantiated MTL neurocognitive networks for complex face and scene perception.

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Citations

Jan 15, 2016·Neuropsychologia·Nazli Esfahani-BayerlChristoph J Ploner
Dec 14, 2016·The American Journal of Gastroenterology·Jasmohan S BajajJames B Wade
Jun 9, 2018·Cognitive Neuropsychology·Guillaume HerbetHugues Duffau
Aug 30, 2018·Hippocampus·Jessica RobinRosanna K Olsen
Apr 18, 2017·Brain and Behavior·Joshua D BurksMichael E Sughrue
May 16, 2017·Autism Research : Official Journal of the International Society for Autism Research·Seraphina K SoldersRalph-Axel Müller
Sep 27, 2019·Frontiers in Neuroscience·Minyoung JungHirotaka Kosaka
Jun 23, 2020·Brain Connectivity·Susan L BenearIngrid R Olson

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Software Mentioned

Featquery
ExploreDTI
3dClustSim
FEAT
FUGUE
FMRIB
FSL
PRELUDE
FMRIB Local Analysis of Mixed Effects
TBSS

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