PMID: 11917225Mar 28, 2002Paper

Dissociated expression of Bcl-2 and Ki-67 in endometrial lesions: diagnostic and histogenetic implications

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Björn RisbergMats G Karlsson

Abstract

The objective of the present study was to analyze the expression of the proliferation marker, Ki-67, and the anti-apoptotic protein, bcl-2, in various endometrial lesions. Ki-67 and bcl-2 expressions were studied in 194 specimens of endometrial hyperplasia, polyps, carcinomas, and cyclic endometrium from a defined geographic area. Results were statistically analyzed with respect to marker expression, localization to the stromal or glandular component, and intraglandular topography. The lowest glandular Ki-67 expression was seen in secretory endometrium, in polyps, and in atypical hyperplasia. The Ki-67 score was significantly higher and less heterogeneous in endometrial carcinomas than in hyperplasia (p<0.001). Endometrial hyperplasia of all types was characterized by a markedly heterogeneous glandular expression of Ki-67. The glandular expression of bcl-2 was highest in proliferative endometrium and polyps. Bcl-2 expression was significantly lower in adenocarcinomas than in hyperplastic lesions (p=0.002). Ki-67 and bcl-2 expression showed a significant association in proliferative endometrium (p=0.003). Endometrial polyps demonstrated a unique pattern of very low expression of Ki-67 and high bcl-2 expression in both stroma and...Continue Reading

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Citations

Jul 20, 2005·Bulletin of Experimental Biology and Medicine·G T SukhikhV P Smetnik
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jianguo Hu, Rui Yuan
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Mar 21, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ayse F Gokmen KarasuGulsah K Ilhan
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Dec 7, 2021·International Journal of Surgical Pathology·Paschalis ChatzipantelisAlexandra Giatromanolaki

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