Dissociated multi-unit activity and local field potentials: a theory inspired analysis of a motor decision task

NeuroImage
Maurizio MattiaPaolo Del Giudice

Abstract

Local field potentials (LFP) and multi-unit activity (MUA) recorded in vivo are known to convey different information about the underlying neural activity. Here we extend and support the idea that single-electrode LFP-MUA task-related modulations can shed light on the involved large-scale, multi-modular neural dynamics. We first illustrate a theoretical scheme and associated simulation evidence, proposing that in a multi-modular neural architecture local and distributed dynamic properties can be extracted from the local spiking activity of one pool of neurons in the network. From this new perspective, the spectral features of the field potentials reflect the time structure of the ongoing fluctuations of the probed local neuronal pool on a wide frequency range. We then report results obtained recording from the dorsal premotor (PMd) cortex of monkeys performing a countermanding task, in which a reaching movement is performed, unless a visual stop signal is presented. We find that the LFP and MUA spectral components on a wide frequency band (3-2000 Hz) are very differently modulated in time for successful reaching, successful and wrong stop trials, suggesting an interplay of local and distributed components of the underlying neur...Continue Reading

References

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Citations

Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maurizio MattiaStefano Ferraina
Jun 22, 2010·NeuroImage·Michael BreakspearGustavo Deco
Mar 19, 2014·Neuroscience and Biobehavioral Reviews·Alexandra Battaglia-MayerTim Shallice
Dec 12, 2019·Frontiers in Systems Neuroscience·Giulia De BonisPier Stanislao Paolucci
May 9, 2019·PeerJ·Sebastiaan Van De VijverMichele Giugliano
Sep 27, 2018·Scientific Reports·Pierpaolo PaniStefano Ferraina
Dec 15, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Franco GiarroccoStefano Ferraina
Feb 27, 2021·Frontiers in Systems Neuroscience·Melody Torao-AngostoMaria V Sanchez-Vives
Jun 24, 2021·Cell Reports·Núria Tort-ColetMaurizio Mattia

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