Dissociation between hysteresivity and tension in constricted tracheal and parenchymal strips

Journal of Applied Physiology
F G Salerno, M S Ludwig

Abstract

The object of this study was to investigate how changes in the contractile state of smooth muscle would modify oscillatory mechanics of tracheal muscle and lung parenchyma during agonist challenge. Guinea pig tracheal and parenchymal lung strips were suspended in an organ bath. Measurements of length (L) and tension (T) were recorded during sinusoidal oscillations under baseline conditions and after challenge with 1 mM ACh. Measurements were also obtained in strips pretreated with the calmodulin inhibitor calmidazolium (Cmz) or staurosporine (Stauro), a protein kinase C inhibitor. Elastance (E) and resistance (R) were calculated by fitting changes in T, L, and DeltaL/Deltat to the equation of motion. Hysteresivity (eta) was obtained from the following equation: eta = (R/E)2pif, where f is frequency. Finally, maximal unloaded shortening velocity during electrical field stimulation was measured in Cmz-pretreated and control tracheal strips. In tracheal strips, pretreatment with Cmz caused a significant decrease in the eta response to ACh challenge and in maximal unloaded shortening velocity measured during electrical field stimulation; Stauro decreased the T, E, and R response to ACh. In parenchymal strips, Cmz decreased the eta ...Continue Reading

References

Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·L A AntonissenN L Stephens
Dec 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H Sasaki, F G Hoppin
Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Apr 1, 1992·Canadian Journal of Physiology and Pharmacology·N L StephensH Jiang
Jan 1, 1992·Journal of Applied Physiology·H JiangN L Stephens
Sep 1, 1991·Journal of Applied Physiology·A M Lauzon, J H Bates
May 1, 1991·The American Review of Respiratory Disease·J L Black
Dec 1, 1989·Journal of Applied Physiology·J J Fredberg, D Stamenovic
Sep 1, 1983·British Journal of Pharmacology·J F BertramJ W Paterson
Aug 1, 1982·British Journal of Pharmacology·R G GoldieJ L Wale
Nov 1, 1994·Canadian Journal of Physiology and Pharmacology·M P WalshK G Morgan
Jun 15, 1994·Molecular and Cellular Biochemistry·M P Walsh
Mar 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R A Murphy
Aug 1, 1993·The American Review of Respiratory Disease·M Souhrada, J F Souhrada
Feb 1, 1993·Journal of Applied Physiology·S M MijailovichJ J Fredberg
Mar 1, 1993·Journal of Applied Physiology·J J FredbergS A Shore
Dec 1, 1996·Journal of Applied Physiology·J J FredbergG C Sieck
Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J Solway, J J Fredberg
Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·T FanN L Stephens

❮ Previous
Next ❯

Citations

Jul 18, 2001·Journal of Applied Physiology·P V RomeroJ Lopez-Aguilar
May 15, 2007·Journal of Applied Physiology·Michael J EmeryErik R Swenson
Jan 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A E BharuchaR D Hubmayr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.