PMID: 2107751Mar 1, 1990Paper

Dissociation between myosin phosphorylation and shortening velocity in canine trachea

The American Journal of Physiology
L MerkelT J Torphy

Abstract

The relationship between glycogen phosphorylase activity (an index of cytosolic Ca2+ content), myosin light-chain phosphorylation, isotonic shortening velocity, and isometric tension was examined in canine trachealis. Responses were measured in tracheal strips contracted with various concentrations of methacholine or K+. Both agonists produced prolonged and concentration-dependent increases in isometric tension that reached 90% of the plateau level within 1 (methacholine) to 5 (K+) min and remained stable over 60 min. In contrast to the monotonic increase in isometric tension, shortening velocity reached a maximum almost immediately (12-48 s) after the addition of either methacholine or K+ and then declined over time to a steady-state level that was 25-40% of the peak. Phosphorylase activity also increased transiently, reaching a maximum 1-2 min after the addition of either agonist before declining to near-basal levels over the 60-min observation period. Unlike the increases in shortening velocity and phosphorylase activity, agonist-induced myosin phosphorylation was not markedly transient. Moreover, regardless of the contractile agonist used, no correlation was found between myosin phosphorylation and shortening velocity when ...Continue Reading

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Citations

Jun 1, 1991·Hypertension·J T StullK E Kamm
Sep 12, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joyce Hojin JangJames G Martin
Feb 1, 1995·Journal of Muscle Research and Cell Motility·K Y Horiuchi, S Chacko
Jun 15, 1994·Molecular and Cellular Biochemistry·H Jiang, N L Stephens
Jun 13, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fulvio R GilAnne-Marie Lauzon
Jul 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·R Marthan
May 19, 2009·Canadian Journal of Physiology and Pharmacology·J BlackG L Wright
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Fulvio R Gil, Anne-Marie Lauzon
May 16, 2002·American Journal of Veterinary Research·Robert J WashabauDaniel J Brockman
Nov 18, 2008·American Journal of Respiratory and Critical Care Medicine·Renaud LéguilletteAnne-Marie Lauzon
Jan 24, 2015·Canadian Journal of Physiology and Pharmacology·Bo LanLinhong Deng
May 23, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ling LuoPasquale Chitano
Aug 13, 1999·The American Journal of Physiology·K A JonesD O Warner

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