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Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Jul 5, 2003

Shin Jung KangJunying Yuan

PMID: 12843244

Abstract

Caspase-11 is a key regulator of caspase-1 and caspase-3 activation under pathological conditions. We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS)...read more

Mentioned in this Paper

SOD1 gene
Casp11 protein, mouse
Founder Mice, Transgenic
Mice, Knockout
Inflammation
Metabolic Inhibition
Interleukin-1 beta
Interleukin-1
CASP3 protein, human
Casp3 protein, mouse
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Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

Jul 5, 2003

Shin Jung KangJunying Yuan

PMID: 12843244

DOI:

Abstract

Caspase-11 is a key regulator of caspase-1 and caspase-3 activation under pathological conditions. We show here that the expression of caspase-11 is upregulated in the spinal cord of superoxide dismutase 1 (SOD1) G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis (ALS)...read more

Mentioned in this Paper

SOD1 gene
Casp11 protein, mouse
Founder Mice, Transgenic
Mice, Knockout
Inflammation
Metabolic Inhibition
Interleukin-1 beta
Interleukin-1
CASP3 protein, human
Casp3 protein, mouse

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