Dissociation between Postrhinal Cortex and Downstream Parahippocampal Regions in the Representation of Egocentric Boundaries

Current Biology : CB
Xenia GofmanDori Derdikman

Abstract

Navigation requires the integration of many sensory inputs to form a multi-modal cognitive map of the environment, which is believed to be implemented in the hippocampal region by spatially tuned cells [1-10]. These cells encode various aspects of the environment in a world-based (allocentric) reference frame. Although the cognitive map is represented in allocentric coordinates, the environment is sensed through diverse sensory organs, mostly situated in the animal's head, and therefore represented in sensory and parietal cortices in head-centered egocentric coordinates. Yet it is not clear how and where the brain transforms these head-centered egocentric representations to map-like allocentric representations computed in the hippocampal region. Theoretical modeling has predicted a role for both egocentric and head direction (HD) information in performing an egocentric-allocentric transformation [11-15]. Here, we recorded new data and also used data from a previous study [16]. Adapting a generalized linear model (GLM) classification [17]; we show that the postrhinal cortex (POR) contains a population of pure egocentric boundary cells (EBCs), in contrast with the conjunctive EBCs × HD cells, which we found downstream mostly in t...Continue Reading

Citations

Jun 26, 2020·Hippocampus·William de Cothi, Caswell Barry
Aug 9, 2020·Nature Reviews. Neuroscience·Andrej Bicanski, Neil Burgess
Mar 5, 2020·Science Advances·Andrew S AlexanderMichael E Hasselmo
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
May 12, 2021·Current Biology : CB·Elhanan Ben-YishayYoram Gutfreund

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