PMID: 1968849Feb 1, 1990

Dissociation between the effect of aceclidine on outflow facility and accommodation

Experimental Eye Research
K A Erickson-Lamy, A Schroeder

Abstract

The dose/effect relationships for intracameral doses of aceclidine HCl and pilocarpine HCl on total facility of outflow and accommodative amplitude were compared in the cynomolgus monkey eye in vivo. The largest dose of aceclidine tested (20 micrograms), resulted in an average increase of 270% in outflow facility, whereas accommodation was limited to an average of 5 diopters. In contrast, 20 micrograms of intracameral pilocarpine (which is submaximal in increasing facility) resulted in an average of 19 diopters of accommodation. These results provide further evidence for a dissociation between the accommodative and outflow facility functions of the ciliary muscle.

References

Jan 1, 1975·Bibliotheca Ophthalmologica : Supplementa Ad Ophthalmologica·J François, F Goes
Jul 1, 1988·Current Eye Research·Paul L KaufmanK A Erickson-Lamy
Aug 1, 1970·The British Journal of Ophthalmology·J H Romano
Oct 1, 1972·Archives of Ophthalmology·S M DranceM Schulzer
Jan 1, 1980·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·G Keren, G Treister
Jul 1, 1984·The Journal of Experimental Zoology·M H Kaufman, I M Bain

Citations

Aug 26, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·H IshikawaP N Patil
Apr 6, 2001·International Ophthalmology Clinics·M A CroftPaul L Kaufman
Dec 15, 2010·Experimental Eye Research·B'Ann T GabeltCarol A Rasmussen
Apr 4, 2008·American Journal of Physiology. Cell Physiology·William M DismukeDorette Z Ellis

Related Concepts

Accommodation, Lens
Aqueous Flare
Dose-Response Relationship, Drug
Macaca fascicularis
Salagen
Quinuclidines

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