PMID: 6180598Aug 1, 1982

Dissociation between the effects of some xanthine derivatives on the tracheal smooth muscle and on the skeletal muscle

Acta Pharmacologica Et Toxicologica
A B JeppssonB Waldeck

Abstract

The ability of some xanthine derivatives to relax the trachea, contracted by pilocarpine, and to increase the force of contraction of directly stimulated skeletal muscles from the guinea-pig was studied in vitro. No relationship was found between these two effects. Relaxation of the trachea occurred at lower concentrations and with a different order of potency as compared with the effects on the slow-contracting soleus muscle or on the fast-contracting extensor digitorum longus. One of the compounds, IBMX, 1-methyl-3-isobutyl-xanthine, showed an isoprenaline-like effect on the soleus muscle i.e. it depressed the force and fusion of subtetanic contractions. The relaxing effect of theophylline and IBMX on the trachea was additive to that of terbutaline but no clear potentiation was observed. The depression of the contraction of the soleus muscle elicited by terbutaline was reinforced by IBMX but not by theophylline. Theophylline in concentrations which used alone enhanced the contractions of the soleus muscle inhibited the effect of terbutaline. We conclude that the relative contribution of the various effects of xanthine derivatives differs from compound to compound.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Mar 1, 1978·Biochemical Pharmacology·D J NewmanJ R Wardell
Nov 1, 1979·The American Journal of Physiology·K D Meisheri, J H McNeill
Oct 1, 1981·Acta Pharmacologica Et Toxicologica·C G PerssonJ A Karlsson
May 1, 1961·The Journal of General Physiology·C P Bianchi
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING

Citations

Feb 1, 1992·Perceptual and Motor Skills·B H Jacobson, S R Thurman-Lacey
Jun 1, 1991·Perceptual and Motor Skills·B H JacobsonH A Gemmell
Jul 1, 1991·Acta Physiologica Scandinavica·A LindénB E Skoogh
Jan 1, 1985·European Journal of Clinical Pharmacology·H J WharradJ L Mead

Related Concepts

Cyclic AMP, (R)-Isomer
Adrenergic beta-Agonists
Dose-Response Relationship, Drug
Cavia porcellus
Inotropism
Muscle
Nerve-Muscle Preparation
Trachea
Xanthines
1-Methyl-3-isobutylxanthine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.