PMID: 6180598Aug 1, 1982

Dissociation between the effects of some xanthine derivatives on the tracheal smooth muscle and on the skeletal muscle

Acta Pharmacologica Et Toxicologica
A B JeppssonB Waldeck


The ability of some xanthine derivatives to relax the trachea, contracted by pilocarpine, and to increase the force of contraction of directly stimulated skeletal muscles from the guinea-pig was studied in vitro. No relationship was found between these two effects. Relaxation of the trachea occurred at lower concentrations and with a different order of potency as compared with the effects on the slow-contracting soleus muscle or on the fast-contracting extensor digitorum longus. One of the compounds, IBMX, 1-methyl-3-isobutyl-xanthine, showed an isoprenaline-like effect on the soleus muscle i.e. it depressed the force and fusion of subtetanic contractions. The relaxing effect of theophylline and IBMX on the trachea was additive to that of terbutaline but no clear potentiation was observed. The depression of the contraction of the soleus muscle elicited by terbutaline was reinforced by IBMX but not by theophylline. Theophylline in concentrations which used alone enhanced the contractions of the soleus muscle inhibited the effect of terbutaline. We conclude that the relative contribution of the various effects of xanthine derivatives differs from compound to compound.


Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Mar 1, 1978·Biochemical Pharmacology·D J NewmanJ R Wardell
Nov 1, 1979·The American Journal of Physiology·K D Meisheri, J H McNeill
Oct 1, 1981·Acta Pharmacologica Et Toxicologica·C G PerssonJ A Karlsson
May 1, 1961·The Journal of General Physiology·C P Bianchi
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING


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Jun 1, 1991·Perceptual and Motor Skills·B H JacobsonH A Gemmell
Jul 1, 1991·Acta Physiologica Scandinavica·A LindénB E Skoogh
Jan 1, 1985·European Journal of Clinical Pharmacology·H J WharradJ L Mead

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