Dissociation constant of the norepinephrine-receptor complex in normotensive and hypertensive rats.

Circulation Research
R B StreckerA M Michelakis

Abstract

Previous reports have suggested that smooth muscle obtained from the thoracic aorta of spontaneously hypertensive rats is less responsive to vasoconstrictive agents than that obtained from normotensive rats. The present study was undertaken to determine whether the responsiveness of aortic muscles from normotensive and spontaneously hypertensive rats correlates with a difference in the affinity of the adrenergic receptors for norepinephrine and whether antihypertensive therapy alters the affinity of the adrenergic receptors for norepinephrine. The affinity of the adrenergic receptors for norepinephrine was determined by computing the dissociation constant of the norepinephrine-receptor complex (KDR). The values computed for KDR in aortic muscles from normotensive and spontaneously hypertensive rats that had received no antihypertensive therapy were 1.07 X 10(-7)M and 1.17 X 10(-7)M, respectively. The values computed for KDR in aortic muscles from normotensive and spontaneously hypertensive rats that had received antihypertensive therapy were 1.38 X 10(-7)M and 1.29 X 10(-7)M, respectively. The differences in these values for KDR are not significant. These results indicate that the difference in the contractility of aortic muscl...Continue Reading

Citations

Nov 1, 2011·Pharmaceutical Research·Ronald J TallaridaRobert B Raffa
Jan 1, 1978·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·C P RobinsonJ Francis
Aug 1, 1984·Acta Physiologica Scandinavica·H Nilsson
Mar 1, 1984·The Journal of Clinical Investigation·R D FeldmanA J Wood
Dec 1, 1986·British Journal of Pharmacology·A M HeagertyJ D Swales
Feb 1, 1977·Biochemical Pharmacology·M S Amer

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