Dissociation in the control of cervical eosinophilic infiltration and collagenolysis at the end of pregnancy or after pseudopregnancy in ovariectomized steroid-treated rats

Biology of Reproduction
E H LuqueM Muñoz de Toro

Abstract

Previous studies have demonstrated that during parturition the physiological ripening that permits dilation of the cervical canal is due to a widespread collagenolysis that follows a heavy polymorphonuclear leukocyte invasion of the uterine cervix. The aim of this study was to investigate whether there is any association between the ovarian steroid hormones involved in rat parturition and this phenomenon. Pregnant or pseudopregnant rats were ovariectomized (OVX) at Day 9 and then given a hormonal treatment (sufficient to maintain fetal viability) until Day 23. Cervical biopsies, taken from animals killed intrapartum or 1 h before expected parturition, were studied for eosinophilic infiltration and collagen birefringence. Intrapartum or sham-OVX pregnant rats showed a massive eosinophilic infiltration and a widespread collagenolysis as indicated by a loss of collagen birefringence. Ovariectomized pregnant rats treated with estrogen plus progesterone or with progesterone alone showed neither infiltration nor collagenolysis. In rats OVX during pseudopregnancy, estrogen given alone induced a significant infiltration of eosinophils in the cervical stroma; however, treatment with the combination of estrogen and progesterone was not a...Continue Reading

Citations

Apr 7, 2005·Journal of Reproductive Immunology·Verónica L BosquiazzoEnrique H Luque
Aug 24, 2002·Biology of Reproduction·Jorge G RamosMónica Muñoz-de-Toro
Mar 7, 2003·Biology of Reproduction·Amanda N Sferruzzi-PerriLindsay A Dent
Feb 21, 2009·Biology of Reproduction·Steven M YellonMichael A Kirby
Jan 9, 1998·Zentralblatt für Veterinärmedizin. Reihe A·E H LuqueG S Montes
Nov 25, 2003·Reproductive Biology and Endocrinology : RB&E·Horacio A RodríguezEnrique H Luque
Mar 21, 2007·Environmental Health Perspectives·Milena DurandoMónica Muñoz-de-Toro
Mar 16, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·J VarayoudE H Luque
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·V L BosquiazzoE H Luque
Jan 23, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jonathan W BoydSteven M Yellon
Sep 23, 2009·Reproduction in Domestic Animals = Zuchthygiene·E van EngelenV P M G Rutten
Dec 26, 2001·Carcinogenesis·C L WalkerB Davis
Nov 16, 2007·Biology of Reproduction·Steven M YellonYukihiko Sugimoto
Feb 11, 2020·Frontiers in Immunology·Steven M Yellon
Dec 5, 2020·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Sarah BlimHartwig Bostedt
Dec 16, 2004·Reproduction in Domestic Animals = Zuchthygiene·A WehrendH Bostedt
Aug 12, 2020·Molecular and Cellular Endocrinology·Bracho Gisela SBosquiazzo Véronica L

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