Dissociation of β1- and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory

Behavioural Brain Research
Michael K FitzgeraldDevin Mueller

Abstract

Drug seeking is maintained by encounters with drug-associated cues, and disrupting retrieval of these drug-cue associations would reduce the risk of relapse. Retrieval of cocaine-associated memories is dependent on β-adrenergic receptor (β-AR) activation, and blockade of these receptors induces a persistent retrieval deficit. Whether retrieval of cocaine-associated memory is mediated by a specific β-AR subtype, however, remains unclear. Using a cocaine conditioned place preference (CPP) procedure, we examined whether retrieval of a cocaine CPP memory is mediated collectively by β1- and β2-ARs, or by one of these β-AR subtypes alone. We show that co-blockade of β1- and β2-ARs abolished CPP expression on that and subsequent drug-free CPP tests, resulting in a long-lasting retrieval deficit that prevented subsequent cocaine-induced reinstatement. To dissociate the necessity of either β1- or β2-ARs alone, we administered subtype-specific antagonists prior to retrieval. Administration of a β1-AR antagonist before the initial CPP trial dose-dependently reduced expression of a CPP on that and subsequent drug-free trials as compared to vehicle administration. In contrast, administration of a β2-AR antagonist had no effect on initial CP...Continue Reading

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Citations

Jan 17, 2016·Brain Research·Rodrigo A EspañaCraig W Berridge
May 4, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M Otis, Devin Mueller
Jul 3, 2018·Frontiers in Behavioral Neuroscience·James M OtisDevin Mueller
Mar 30, 2017·Frontiers in Behavioral Neuroscience·Huiwen ZhuXing Liu
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Brooke N Bender, Mary M Torregrossa
Mar 5, 2021·The European Journal of Neuroscience·Verónica Pastor, Jorge Horacio Medina
Aug 22, 2021·Behavioural Pharmacology·Stephanie L GrellaDiano F Marrone

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