Dissociation of alcohol-seeking and consumption under a chained schedule of oral alcohol reinforcement in baboons.

Alcoholism, Clinical and Experimental Research
Barbara J KaminskiElise M Weerts

Abstract

Initiation and maintenance of compulsive alcohol drinking involves a sequence of behaviors which occur in the presence of environmental cues. Animal models using chained schedules of alcohol reinforcement may be useful for examining the complex interactions between cues and alcohol-seeking and -consumption. Four baboons self-administered alcohol under a 3-component chained schedule of reinforcement; distinct cues were presented in the context of different behavioral contingencies associated with gaining access to 4% w/v alcohol (alcohol-seeking) and concluding with alcohol self-administration. First, the response strength of alcohol-related seeking responses was evaluated using a between-sessions progressive ratio (PR) procedure in which the response requirement to initiate the final contingency and gain access to the daily supply of alcohol was increased each session. The highest response requirement completed that resulted in alcohol access was defined as the breaking point (BP). Second, water was substituted for alcohol and PR procedures were repeated. The effects of increasing the "seeking" response requirement on subsequent alcohol or water consumption were also determined. When alcohol was available, operant responses to ...Continue Reading

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Citations

Mar 28, 2012·Psychopharmacology·Barbara J KaminskiElise M Weerts
Mar 1, 2016·Current Addiction Reports·Theresa H McKimCharlotte A Boettiger
Sep 17, 2013·Alcoholism, Clinical and Experimental Research·Barbara J Kaminski, Elise M Weerts
Jun 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chiara GiulianoBarry J Everitt
Aug 10, 2015·Alcohol·Richard J LambBrett C Ginsburg
Sep 3, 2014·Physiology & Behavior·Ricardo Marcos PautassiMichael Nizhnikov

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