PMID: 108734Mar 22, 1979

Dissociation of autonomic and cognitive effects of THC in man

Psychopharmacology
J BachmanR T Jones

Abstract

Intravenous THC, 30--44.8 microgram/kg, was administered to four subjects. Each received THC on four occasions preceded by either i.v. saline, 0.04 mg/kg atropine sulfate, 0.2 mg/kg propranolol, or both drugs together. Heart rates, subjective intoxication and symptom ratings, time productions, and EEG activity were measured. In the absence of autonomic blocking drugs, THC produced characteristic tachycardia, subjective intoxication, and EEG effects. After combined autonomic blockade, THC had no effect on heart rate, while subjective and EEG changes remained as intense. These findings argue against the hypothesis that the subjective and EEG effects of THC are mediated by autonomic receptors or by interoception of peripheral autonomic actions of THC.

References

Mar 23, 1977·Psychopharmacology·A SulkowskiE S Rich
Apr 1, 1979·Clinical Pharmacology and Therapeutics·N BenowitzR T Jones
Jan 1, 1976·Annals of the New York Academy of Sciences·R T JonesJ Bachman
Aug 3, 1972·The New England Journal of Medicine·P BeaconsfieldR Rainsbury
Jul 1, 1972·Clinical Pharmacology and Therapeutics·W G DrewM Marx
Jan 1, 1974·Pharmacology·W G Drew, L L Miller
Aug 22, 1973·Psychopharmacologia·J VolavkaM Fink
Nov 1, 1969·The Journal of Clinical Investigation·A D Jose, R R Taylor

Citations

Aug 17, 2011·Psychopharmacology·Michelle CarbutoYale THC Study Group
Jan 16, 2013·Drug Metabolism and Pharmacokinetics·Rongrong JiangKazuhito Watanabe
Jan 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·T E WilensT J Spencer
Sep 16, 2016·Behavioural and Cognitive Psychotherapy·Lydia R M FrenchKatrina M Turner
Jul 14, 2020·Cannabis and Cannabinoid Research·Marieka V DeVuono, Linda A Parker

Related Concepts

Atropine Sulfate Anhydrous
Autonomic Nervous System
Cognition
Drug Interactions
Electroencephalogram
Pulse Rate
Hemodynamics
Rexigen
Tetrahydrocannabinol, (6a-trans)-Isomer
Time Perception

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