PMID: 7540847Mar 1, 1995Paper

Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats

American Journal of Hypertension
N YokotaA J De Bold

Abstract

We examined the relationship between cardiac hypertrophy, myosin heavy chain (MHC) isoform expression, and production of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) before and after the development of DOCA-salt hypertension. DOCA-salt rats exhibited significant left ventricular hypertrophy at the prehypertensive stage (1 week of treatment), without MHC isoform switch or change in natriuretic peptide gene expression. In the hypertensive stage (5 weeks of treatment), pronounced left ventricular hypertrophy was observed, and this was characterized by an increase in beta-MHC protein, resulting in a switch from 90% alpha-MHC to 51% alpha-MHC and 49% beta-MHC. ANF and BNP mRNA levels and peptide content were significantly increased at this stage. Unexpectedly, the MHC isoform switch was evident in the non-hypertrophied right ventricle to the same degree as in the left ventricle. Natriuretic peptide production was also increased in the right ventricle at 5 weeks of treatment, but to a lesser degree than in the left ventricle. In contrast, in the hypertrophied left atrium there was no MHC isoform switch, while ANF and BNP mRNA levels were augmented. Plasma ANF was significantly increased in the prehypertensive s...Continue Reading

Citations

Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Liliana G Bianciotti, Adolfo J de Bold
Apr 11, 2014·American Journal of Physiology. Renal Physiology·Theo DemerathFrank Schweda
May 24, 2020·Nature Reviews. Cardiology·Jens P GoetzeAdolfo J de Bold
Dec 30, 1998·Journal of Cardiovascular Pharmacology·T OgawaA J de Bold
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L G Bianciotti, A J De Bold
Jun 11, 1999·The American Journal of Physiology·T OgawaA J de Bold
Apr 30, 1998·Circulation Research·K L VikstromL A Leinwand
Mar 10, 2001·Biological Research for Nursing·S D Kim, M R Piano
Jun 6, 2003·Endocrine Reviews·Heikki Ruskoaho
Nov 22, 2005·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Adolfo J de Bold, Mercedes L Kuroski de Bold
Apr 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo OgawaAdolfo J de Bold
Nov 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·S BricksonR L Moss
Dec 20, 2012·Journal of Transplantation·Tsuneo Ogawa, Adolfo J de Bold
Jan 22, 1998·The American Journal of Physiology·B G BruneauA J de Bold
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·N S BissoliA M Cabral
May 25, 2005·Peptides·Monica Forero McGrath, Adolfo J de Bold

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