Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

Cell
Maria GenanderJonas Frisén

Abstract

Signaling proteins driving the proliferation of stem and progenitor cells are often encoded by proto-oncogenes. EphB receptors represent a rare exception; they promote cell proliferation in the intestinal epithelium and function as tumor suppressors by controlling cell migration and inhibiting invasive growth. We show that cell migration and proliferation are controlled independently by the receptor EphB2. EphB2 regulated cell positioning is kinase-independent and mediated via phosphatidylinositol 3-kinase, whereas EphB2 tyrosine kinase activity regulates cell proliferation through an Abl-cyclin D1 pathway. Cyclin D1 regulation becomes uncoupled from EphB signaling during the progression from adenoma to colon carcinoma in humans, allowing continued proliferation with invasive growth. The dissociation of EphB2 signaling pathways enables the selective inhibition of the mitogenic effect without affecting the tumor suppressor function and identifies a pharmacological strategy to suppress adenoma growth.

References

May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Dec 28, 2002·Genes & Development·Maria A CiemerychPiotr Sicinski
May 20, 2005·Nature·Vanessa DepaepePierre Vanderhaeghen
Jun 11, 2005·The Journal of Biological Chemistry·Owen J SansomAlan R Clarke
Jun 24, 2005·Nature·Eduard BatlleHans Clevers
Jul 6, 2005·Molecular and Cellular Neurosciences·Lene K Harbott, Catherine D Nobes
Jul 16, 2005·Growth Factors·Christopher J Vearing, Martin Lackmann
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adrian M JubbHartmut Koeppen
Feb 18, 2006·Molecular and Cellular Neurosciences·Jerome RicardDaniel J Liebl
May 18, 2006·Molecular and Cellular Biology·Zhiping LiRichard G Pestell
Jun 3, 2006·Cancer Research·Divyamani Srinivasan, Rina Plattner
Jul 25, 2006·Nature Cell Biology·Nicole K NorenElena B Pasquale
Sep 20, 2006·Cancer Research·Veronica DavalosDiego Arango
Oct 19, 2006·Cancer Research·Zhiping LiRichard G Pestell
Nov 6, 2007·Critical Reviews in Oncology/hematology·Erin A Donovan, Shivaani Kummar
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael J ChumleyMark Henkemeyer
Mar 14, 2008·The New England Journal of Medicine·Fortunato Ciardiello, Giampaolo Tortora
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jian-Wei JiaoDong Feng Chen

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Citations

Mar 27, 2010·International Journal of Colorectal Disease·Paul V SeniorSteven T F Chan
Nov 12, 2013·Experimental Cell Research·Sahiti ChukkapalliMustapha Kandouz
Jan 16, 2013·Cell Research·Elisabeth BouchéHans H Bock
Apr 22, 2011·Nature·Benjamin K AttwoodRobert Pawlak
Aug 19, 2011·Nature Communications·Sonal ThakarMark Henkemeyer
Feb 25, 2010·Nature Reviews. Cancer·Elena B Pasquale
Jan 1, 2014·Nature Reviews. Drug Discovery·Andrew W BoydMartin Lackmann
Jun 23, 2012·Neuro-oncology·Arend H SikkemaEveline S J M de Bont
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Karyn L Sheaffer, Klaus H Kaestner
Nov 17, 2010·Genes & Development·Mara E Pitulescu, Ralf H Adams
Apr 2, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Luke Truitt, Andrew Freywald
Mar 19, 2011·Circulation Research·Polina GoichbergAnnarosa Leri
Nov 1, 2011·Cell Communication and Signaling : CCS·Jens RauchWalter Kolch
May 23, 2012·Clinical Sarcoma Research·Barbara DewaeleRaf Sciot
Jun 4, 2011·PloS One·Christian NiehageBernard Hoflack
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy Catchpole, Mark Henkemeyer
Sep 4, 2013·Regenerative Medicine·Graça Almeida-PoradaChristopher D Porada
Feb 12, 2013·Biochimica Et Biophysica Acta·Jessica E LisleSally-Anne Stephenson
Jul 7, 2014·Nature Methods·Alan ShawAna I Teixeira
May 6, 2014·Cellular and Molecular Life Sciences : CMLS·Erika GucciardoKaisa Lehti
Feb 16, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evan CollettiGraça Almeida-Porada
Dec 29, 2011·Cellular and Molecular Life Sciences : CMLS·Eva NievergallPeter W Janes
Jan 23, 2016·Nature Reviews. Molecular Cell Biology·Artur Kania, Rüdiger Klein
Nov 14, 2012·Molecular and Cellular Neurosciences·Nishi SrivastavaChristopher W Cowan
Nov 2, 2011·Seminars in Cell & Developmental Biology·Jeffrey O Bush, Philippe Soriano
Feb 5, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yong-qiang HuaLu-ming Liu
Sep 3, 2010·Current Opinion in Cell Biology·Maria Genander, Jonas Frisén
Apr 20, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frank BoschelliCarlo Gambacorti-Passerini
Dec 9, 2015·Trends in Cancer·Jun Wang, Ann Marie Pendergast
Jan 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Symone San MiguelM Douglas Benson
Aug 7, 2012·Journal of Cellular and Molecular Medicine·Hong-Qing XiLin Chen
Nov 27, 2015·Molecular Genetics and Genomics : MGG·Seung-Soo KimCheol-Koo Lee
Dec 9, 2014·Cell Adhesion & Migration·David G Wilkinson
Jun 20, 2015·Cellular and Molecular Life Sciences : CMLS·Javier Terriente, Cristina Pujades
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yuan YuanSen-Lin Chen
Jul 8, 2015·Developmental Neurobiology·Michael A RobichauxChristopher W Cowan
Jul 22, 2015·The Journal of Cell Biology·Marie-Thérèse ProspériEvelyne Coudrier
Jun 19, 2012·Biochimica Et Biophysica Acta·Brigitte GerardMalathy P V Shekhar

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