Abstract
Exercise treadmill tests and ambulatory monitoring were used in a double-blind, placebo-controlled, double-dummy crossover comparison of nifedipine (10 mg, 3 times daily) and transdermal nitroglycerin (15 mg). All patients (n = 20) had chronic stable angina with symptomatic and silent events. All patients had 3 episodes of angina/week and 3 episodes of ischemia/24 hr. The protocol was made up of 2 weeks of placebo followed by 2 weeks of active drug, then crossed over for 2 weeks of placebo followed by the other active drug. At the end of each 2-week period, patients had ambulatory monitoring and exercise treadmill testing. All ambulatory monitoring reports were read blind and entered into an independent data base. The results were the following: on transdermal nitroglycerin, the duration of ischemia decreased by 57% from 140 min/24 hr to 60 min/24 hr (p = 0.0054). The exercise time increased by 5.5% from 4.8 to 5.0 minutes (p = 0.16). With nifedipine, the duration of ischemia decreased by 22% from 175 min/24 hr to 137 min/24 hr (p = 0.16). The exercise tolerance time increased by 13% from 4.5 to 5.0 minutes (p = 0.0264). Nifedipine increased exercise time without altering total ischemic time, while transdermal nitroglycerin dec...Continue Reading
References
Nov 1, 1975·American Heart Journal·T Winsor, H J Berger
Aug 1, 1976·Circulation·A MaseriA Pesola
May 1, 1986·Circulation·J E GageH P Krayenbuehl
Apr 1, 1969·Circulation·M H EllestadG L Kemp
Dec 1, 1984·The American Journal of Cardiology·J E DeanfieldA P Selwyn
Jul 1, 1984·The American Journal of Cardiology·N ReichekM S Sutton
Mar 1, 1980·Circulation·U ThadaniH L Fung
Oct 1, 1981·The American Journal of Medicine·H J DargieS Krikler
Citations
Aug 1, 1991·Journal of Clinical Pharmacology·D Rinde-HoffmanD K Arnett
Mar 1, 1996·Cardiovascular Drugs and Therapy·T O Klemsdal, K Gjesdal
Dec 1, 1992·Cardiovascular Drugs and Therapy·T O Klemsdal, K Gjesdal
Oct 1, 1994·Cardiovascular Drugs and Therapy·H PurcellK Fox
Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Jun 1, 1993·Journal of the American College of Cardiology·S BorzakP H Stone
Feb 1, 1993·Journal of the American College of Cardiology·E RossettiS L Chierchia
Jan 1, 1994·British Heart Journal·H IkramR J Horsburgh
Nov 1, 1996·Heart·H Ikram
Jun 1, 1994·The American Journal of Cardiology·B TakaseY Kanda
Sep 24, 1992·The American Journal of Cardiology·C J Pepine
Nov 1, 1992·International Journal of Cardiology·B TakaseT Kodaira
Jul 1, 1994·American Heart Journal·N J Mangione, S P Glasser
Aug 5, 2000·Primary Care·L Kuritzky
Jan 1, 1992·European Journal of Clinical Pharmacology·B G WoodcockN Reifart