PMID: 2425861Mar 1, 1986

Dissociation of insulin binding from insulin stimulation of 2-deoxyglucose transport by ruthenium red

Bioscience Reports
P F WilliamsJ R Turtle

Abstract

Ruthenium red increased specific insulin binding to isolated adipocytes 5.4 fold and 2.6 fold over binding determined in the absence and presence of Ca2+ and Mg2+. The increase in insulin binding was not accompanied by an increase in insulin sensitivity. The lack of effect of ruthenium red on insulin action argued strongly against an increase in intracellular Ca2+ as a potential messenger/transducer of insulin action and suggested that the enhancing effect of Ca2+ on insulin action was a result of increased receptor affinity.

References

Feb 1, 1978·Biological Reviews of the Cambridge Philosophical Society·F L Bygrave
May 1, 1979·Quarterly Reviews of Biophysics·R B Martin, F S Richardson
Aug 28, 1979·Biochimica Et Biophysica Acta·P F Williams, J R Turtle
Sep 1, 1978·Canadian Journal of Biochemistry·K S DesaiC H Hollenberg
Dec 3, 1971·Biochimica Et Biophysica Acta·E L WatsonP W Davis
Jan 21, 1972·Biochimica Et Biophysica Acta·F D VasingtonE Carafoli
Jan 1, 1980·Journal of Cardiovascular Pharmacology·C F PengM L Murphy
Jan 30, 1981·The Journal of Membrane Biology·T R HindsF F Vincenzi
Aug 15, 1983·The Biochemical Journal·W E PlehweJ R Turtle
Jan 24, 1984·Biochimica Et Biophysica Acta·P F WilliamsJ R Turtle
Oct 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K Siddle, C N Hales
Aug 5, 1981·Biochimica Et Biophysica Acta·P F Williams, J R Turtle

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