PMID: 6163874Feb 1, 1981Paper

Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells

Journal of Virology
C W CzarnieckiA Panet

Abstract

Two subclones of Swiss mouse cells infected with Moloney murine leukemia virus (M-MuLV) were tested for their response to interferon (IFN). Whereas M-MuLV production in the two subclones was inhibited to the same extent, one of the subclones was significantly more sensitive to IFN when the antiviral effect was measured by replication of encephalomyocarditis (EMC) virus. The same subclone was also more sensitive to the anticellular activities of IFN. Additionally, NIH 3T3 cells infected with M-MuLV were completely resistant to IFN actions when EMC virus replication or the anticellular activities were tested. However, under the same conditions, M-MuLV production was completely inhibited by IFN. These results indicate that IFN may affect cell growth functions and EMC replication through mechanisms different from those by which MuLV production is inhibited.

Citations

Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Y TomitaT Kuwata
Jan 1, 1982·Journal of Interferon Research·J W ScottM R Proffitt
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·N MorinagaT Kuwata
Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C J PfauJ K Valenti
Jan 1, 1982·Archives of Virology·L W Mozes
Jan 1, 1982·Journal of Interferon Research·D K BanerjeeR M Friedman
Dec 1, 2009·Viruses·Esperanza Gómez-LucíaAna Doménech
Mar 1, 1983·Journal of Virology·G C Sen, R E Herz
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.