PMID: 7009025Jul 1, 1980Paper

Dissociation of renin--aldosterone and renal prostaglandin E during volume expansion induced by immersion in normal man

Clinical Science
M EpsteinE Haber

Abstract

The relationship of the renin--angiotensin--aldosterone axis with renal prostaglandin E is complex. Although studies have suggested that these two hormonal systems respond to experimental manipulations in a parallel manner, their interdependence has not been assessed fully during volume expansion. Since studies have demonstrated that in normal man the central hypervolaemia induced by water immersion to the neck produces a prompt and profound suppression of plasma renin activity and plasma aldosterone concentration without concomitant alteration of plasma composition, immersion afforded a unique opportunity to assess simultaneously the effects of central hypervolaemia on plasma renin activity, plasma aldosterone concentration and prostaglandin E excretion. 2. Seven normal subjects were studied twice while in balance on a diet containing 10 mmol of sodium/day, 100 mmol of potassium/day: with indomethacin administration (50 mg given every 6 h for five doses) and without indomethacin. Urinary prostaglandin E excretion was measured hourly and plasma renin activity and plasma aldosterone concentration at 30 min intervals. 3. Immersion was associated with a marked suppression of plasma renin activity (59 +/- 7%) and plasma aldosterone...Continue Reading

Citations

Oct 1, 1981·The Journal of Pediatrics·J M Bergstein, M H Weinberger
Dec 22, 1986·Physical Review Letters·J Javanainen
Aug 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hiroshi Kuratsuji

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