PMID: 46240Jan 1, 1975

Dissociation of the immunologic release of histamine and slow reacting substance of anaphylaxis from human lung using cytochalasins A and B-1

The Journal of Immunology : Official Journal of the American Association of Immunologists
R P Orange


Cytochalasins A and B at low doses resulted in enhancement of the antigen-induced and anti-IgE-mediated release of histamine from human lung fragments in vitro. Both compounds appeared to effect a dose-dependent inhibition of the antigen-induced release of slow reacting substance of anaphylaxis. Although the effects observed with cytochalasin B were at least partially reversible, the effects of cytochalasin A could not be readily reversed. The cytochalasins appeared to be more effective when present during the antigen-dependent activation phase of mediator release rather than during the calcium-dependent release phase.

Related Concepts

Histamine Measurement
Anti-Immunoglobulin E antibody
Calcium [EPC]
Immune Sera
Immunoglobulin E
Mediator of activation protein

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.