PMID: 6412229Sep 1, 1983Paper

Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad

Proceedings of the National Academy of Sciences of the United States of America
C GlassD Steinberg

Abstract

The metabolic fate of homologous high density lipoprotein (HDL) was studied in the rat, tracing the apoprotein A-I (apo A-I) and cholesterol ester moieties simultaneously. The apo A-I was labeled with covalently linked 125I-labeled tyramine cellobiose, which accumulates in the cells degrading the apoprotein; [3H]cholesterol ethers, which cannot be hydrolyzed or mobilized after uptake, were incorporated into the lipid core of reconstituted HDL to reflect the fate of the cholesterol esters. Several lines of evidence, including direct comparison with biologically labeled HDL, are presented to support the validity of this approach. The liver was the major organ of cholesterol ether uptake, accounting for 65% of the total; the adrenal gland and ovary were the most active organs per gram (wet) of weight. Uptake of cholesterol ether was 7-fold greater than that of apo A-I in adrenal, 4-fold greater in the ovary, and greater than 2-fold greater in the liver. The remaining tissues took up apo A-I and cholesterol ethers at more nearly equal rates. Transfer of HDL-associated cholesterol ethers and 125I-labeled apo A-I to other lipoprotein fractions was not observed; thus, the results reflect direct uptake from HDL itself. Whereas uptake o...Continue Reading

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Citations

Jan 1, 1988·Journal of Inherited Metabolic Disease·A M Salter, D N Brindley
Dec 30, 2009·Histochemistry and Cell Biology·Clemens RöhrlClaudia Meisslitzer-Ruppitsch
Apr 15, 1988·Biochimica Et Biophysica Acta·M BentejacM C Delachambre
Dec 16, 1988·Biochimica Et Biophysica Acta·S K EricksonA Trentalance
Nov 6, 1989·Biochimica Et Biophysica Acta·G GhiselliA M Gotto
Nov 12, 1990·Biochimica Et Biophysica Acta·S AzharE Reaven
Jun 14, 1990·Biochimica Et Biophysica Acta·R Wishart, M Mackinnon
Apr 2, 1990·Biochimica Et Biophysica Acta·C P Sparrow, R C Pittman
Oct 1, 1991·Biochimica Et Biophysica Acta·W J JohnsonM C Phillips
Nov 11, 1992·Biochimica Et Biophysica Acta·L Brissette, L Falstrault
Apr 8, 1992·Biochimica Et Biophysica Acta·T Gjøen, T Berg
Apr 19, 1996·Biochimica Et Biophysica Acta·A BarransX Collet
May 20, 1996·Biochimica Et Biophysica Acta·M M HussainA Bakillah
Nov 1, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·P S Bachorik, P O Kwiterovich
Jan 1, 1994·Pharmacology & Therapeutics·G FranceschiniL Calabresi
Feb 1, 1986·Molecular and Cellular Endocrinology·I E TóthL G Szollár
Mar 1, 1987·Molecular and Cellular Endocrinology·R C Pedersen, A C Brownie
Jun 24, 1987·Biochimica Et Biophysica Acta·M C PhillipsG H Rothblat

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