PMID: 8971486Jan 1, 1995Paper

Dissociation of two actions in the positive effect of prior partial hepatectomy on the induction of the hepatocarcinogenic process by diethylnitrosamine

Epithelial Cell Biology
P ServaisP Galand

Abstract

The present study was aimed at re-evaluating the mechanism by which partial hepatectomy (PH) and the resulting mitogenic stimulation act to positively modulate the action of a chemical hepatocarcinogen applied 24 hours after surgery. Using as a marker the immunocytochemical expression of glutathione S-transferase placental form (GST-P), we compared the early incidence of single altered hepatocytes and the time-course of appearance and growth of subsequently developed liver neoplasia in diethylnitrosamine (DENA) treated sham-operated or partially hepatectomized animals. The data showed that, compared to sham-operation, partial hepatectomy increases the frequency of early GST-P positive single hepatocytes appearing 72 h after treatment with DENA (50 mg/kg b.w.), indicating a positive (co-carcinogenic) effect of PH on the frequency of the initiation event. At 2 months after this treatment, foci of altered hepatocytes were about 5 times more numerous in PH-pretreated than in sham-operated animals and their average volume about four times greater. The latter difference persisted for up to 10 months after carcinogen treatment, indicating that the lesions had grown at similar rates in the meantime. The simplest hypothesis to account f...Continue Reading

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