PMID: 6979046Mar 1, 1982Paper

Dissociation of two signals required for activation of resting B cells

Proceedings of the National Academy of Sciences of the United States of America
M H JuliusC L Sidman

Abstract

Cellular interactions involved in the T cell-dependent activation of B cells were analyzed by using lines and clones of helper T cells specific for determinants expressed on the B cell surface. Activation of male antigen-, M locus-, and H-2-specific T cells was shown to support polyclonal Ig production by a population of B cells that did not require T-cell-B-cell interaction for induction/amplification. However, these T cells alone did not activate gradient-purified small (resting) B cells. The activation of small B cells was shown to require not only a signal derived through an antigen-specific T-helper cell-B cell interaction but in addition a second signal that could be provided by anti-Ig antibodies.

References

Sep 1, 1979·European Journal of Immunology·M H Julius, A A Augustin
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C L Sidman, E R Unanue
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
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Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Jul 1, 1986·Journal of Clinical Immunology·D Y Leung, R S Geha
Jan 1, 1986·Springer Seminars in Immunopathology·R H ZublerP A Miescher
Jan 1, 1986·Immunologic Research·C A Pennell, D W Scott
Jan 1, 1988·Immunologic Research·J G Monroe, V L Seyfert
May 1, 1990·Research in Immunology·E C SnowK E Pollok
May 1, 1990·Research in Immunology·M K Crow, S M Friedman
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleE S Vitetta
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L LeclercqJ Thèze
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N J LoCascioR B Corley
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R B CorleyG Haughton
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·G A Bishop, G Haughton
Jun 1, 1983·The Journal of Experimental Medicine·G J Prud'hommeA N Theofilopoulos
Mar 1, 1984·The Journal of Experimental Medicine·A L DeFrancoW E Paul
Nov 1, 1986·The Journal of Experimental Medicine·M K CrowS M Friedman
Sep 1, 1989·The Journal of Experimental Medicine·J C Cambier, K R Lehmann
Jun 1, 1990·The Journal of Experimental Medicine·J R TumangS M Friedman
Nov 1, 1989·The Journal of Clinical Investigation·E K ChartashS M Friedman
Jul 1, 1983·Annales d'immunologie·A Schimpl
Jul 1, 1984·Annales d'immunologie·C MartinezP Pereira
Jan 1, 1987·Annals of the New York Academy of Sciences·J C CambierM K Newell
Jul 27, 2000·Seminars in Immunology

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