Dissociative mechanism for irreversible thermal denaturation of oligomeric proteins

Biophysics Reviews
Natalia A ChebotarevaBoris I Kurganov

Abstract

Protein stability is a fundamental characteristic essential for understanding conformational transformations of the proteins in the cell. When using protein preparations in biotechnology and biomedicine, the problem of protein stability is of great importance. The kinetics of denaturation of oligomeric proteins may have characteristic properties determined by the quaternary structure. The kinetic schemes of denaturation can include the multiple stages of conformational transitions in the protein oligomer and stages of reversible dissociation of the oligomer. In this case, the shape of the kinetic curve of denaturation or the shape of the melting curve registered by differential scanning calorimetry can vary with varying the protein concentration. The experimental data illustrating dissociative mechanism for irreversible thermal denaturation of oligomeric proteins have been summarized in the present review. The use of test systems based on thermal aggregation of oligomeric proteins for screening of agents possessing anti-aggregation activity is discussed.

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Citations

Dec 8, 2017·PloS One·Valeriya V MikhaylovaBoris I Kurganov
Feb 27, 2018·Physical Chemistry Chemical Physics : PCCP·Karin JuliusRoland Winter
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Jul 7, 2019·International Journal of Biological Macromolecules·Natalia A ChebotarevaBoris I Kurganov
Aug 31, 2019·Progress in Biophysics and Molecular Biology·L Alaei, Ali A Moosavi-Movahedi

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