Dissolution characteristics of megaloporous tablets prepared with two kinds of matrix granules

Il Farmaco
Işik OzgüneyTamer Güneri

Abstract

The purpose of this study is to obtain a drug release at a constant rate with a megaloporous tablet, which was prepared with a simple formulation. These tablets were prepared with two kinds of granules. One of them is the restraining-phase matrix granule (RMG) and it controls the release rate of the drug. The other one is the soluble housing-phase matrix granule (HMG) and controls liquid penetration into the system. Eudragit RL 100 and Eudragit L 100 polymers were used to constitute the restraining and housing matrix phases, respectively. The effect of the amount of Eudragit RL 100 in the RMG was investigated and decreasing of amount of Eudragit RL 100 in the RMG increased the drug release rate. The tablets were prepared with compaction pressures of 188, 377, 1884 and 7540 kg/cm(2) and it was observed that the compaction forces ranging from 377 to 7540 kg/cm(2) did not influence drug release. The effect of the size of the matrices was demonstrated and it was found that the drug release rate increased with decreasing of the size of the tablets. The impact of the dosage to the dissolution rates was also investigated using two different amounts of drug. Therefore, the tablets were designed with two different dosages to use once or...Continue Reading

References

Apr 1, 1992·Journal of Pharmaceutical Sciences·J M Marentette, A E Grosser
Nov 1, 1966·Journal of Pharmaceutical Sciences·E K Thiemer, S P Eriksen
Nov 1, 1966·Journal of Pharmaceutical Sciences·J R Robinson, S P Eriksen
Mar 1, 1997·The Journal of Pharmacy and Pharmacology·G ErtanT Güneri

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Citations

Mar 31, 2010·AAPS PharmSciTech·Esra Baloğlu, Taner Senyiğit
Dec 29, 2007·Pharmaceutical Development and Technology·Mine OzyaziciDogan Ozyurt
Sep 9, 2008·Journal of Pharmaceutical and Biomedical Analysis·János BajdikKlára Pintye-Hódi
Apr 20, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mine OzyaziciGökhan Ertan
Aug 23, 2008·Pharmaceutical Development and Technology·Diego GallardoPeter Kleinebudde

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