Dissolution enhancement by bio-inspired mesocrystals: the study of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate.

Pharmaceutical Research
Tu Lee, Chyong Wen Zhang

Abstract

The aim of this paper is to enhance the dissolution rate of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate via a bio-inspired method of growing mesocrystals. Mesocrystals of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate were successfully prepared from a supersaturated aqueous solution of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate having the initial degree of supersaturation, S ( 0 ), of 1.326 and the initial saturated concentration, C*, of 0.986 mol/l at 25 degrees C with sodium dodecyl sulfate (SDS) at a concentration of 0.10 g/l. Dynamic light scattering, scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and optical microscopy with cross polarizers were employed to understand the formation mechanism and to characterize the superstructures of the SDS generated mesocrystals. The SDS generated mesocrystals were the assembly of the oriented attachment of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate nano-sized platelets under the mediation of the side-to-side interaction between SDS and racemic (R,S)-(+/-)-sodium ibuprofen dihydrate. The SDS generated mesocrystals contained a mixture of the racemic compounds in alpha- and beta-forms and the resolved racemic conglomerate in gamma-form...Continue Reading

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Citations

May 26, 2012·Journal of Pharmaceutical Sciences·Hyemin ChoiJonghwi Lee
Feb 20, 2010·Nature Reviews. Drug Discovery·Steven M PaulAaron L Schacht
Oct 21, 2011·International Journal of Toxicology·Lorrene A BuckleyJanice A Lansita
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Mar 1, 2012·The Journal of Physical Chemistry Letters·Lei Zhou, Paul O'Brien
Dec 18, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Fei TaoPeng Yang

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