Dissolving polymer microneedle patches for influenza vaccination.

Nature Medicine
Sean P SullivanMark R Prausnitz

Abstract

Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.

References

Mar 15, 1982·Toxicology and Applied Pharmacology·R L BronaughE R Congdon
Nov 1, 1994·Chest·P M FlynnB G Williams
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellSampsa Matikainen
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Dec 11, 1952·The New England Journal of Medicine·H A RAVINJ FINE
Mar 25, 2004·Nature Reviews. Immunology·Thomas S Kupper, Robert C Fuhlbrigge
Nov 5, 2004·The New England Journal of Medicine·Robert B BelsheGary Dubin
Jan 5, 2005·The Journal of Experimental Medicine·Rong ZengWarren J Leonard
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Hwan ParkMark R Prausnitz
Sep 1, 2005·Biomedical Microdevices·Takaya MiyanoKatsumi Hanada
Oct 22, 2005·Nature Reviews. Immunology·Samir Mitragotri
Aug 3, 2006·Journal of Drug Targeting·Yukako ItoKanji Takada
Jul 12, 2007·Seminars in Immunopathology·Lloyd S Miller, Robert L Modlin
Aug 23, 2007·Nature Immunology·Peter D KatsikisBali Pulendran
Feb 12, 2008·Biomaterials·Jeong W LeeMark R Prausnitz
Aug 22, 2008·The Clinical Journal of Pain·Harvinder S GillMark R Prausnitz
Sep 20, 2008·The Journal of Clinical Investigation·Peter C Doherty, Anne Kelso
Nov 11, 2008·Nature Biotechnology·Mark R Prausnitz, Robert Langer
Mar 11, 2009·PloS One·Dimitrios G KoutsonanosIoanna Skountzou
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qiyun ZhuRichard W Compans
Sep 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodi McGill, Kevin L Legge
Sep 22, 2009·Current Topics in Microbiology and Immunology·Mark R PrausnitzAlexander K Andrianov
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A J Dean, R J Chenery
Mar 1, 2008·Advanced Materials·Sean P SullivanMark R Prausnitz

❮ Previous
Next ❯

Citations

Jan 15, 2013·Current Allergy and Asthma Reports·Linda CoxMark Larche
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·Jagadeesh Bayry
Apr 18, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jae-Min SongSang-Moo Kang
Sep 3, 2010·Nature Reviews. Drug Discovery·Man Tsuey Tse
Jan 1, 2013·Nature Reviews. Drug Discovery·Harald von Boehmer, Carolin Daniel
Feb 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Veronique BachyLinda S Klavinskis
Jun 21, 2011·The Journal of Infectious Diseases·Dimitrios G KoutsonanosIoanna Skountzou
Jul 19, 2013·Clinical and Vaccine Immunology : CVI·Fu-Shi QuanSang-Moo Kang
Feb 4, 2011·Clinical and Vaccine Immunology : CVI·William C WeldonRichard W Compans
Feb 11, 2011·Clinical and Vaccine Immunology : CVI·Gopalan JagadeeshDipshikha Chakravortty
Dec 25, 2010·The Journal of Clinical Investigation·Stuart N Isaacs
Dec 19, 2013·PloS One·Satoshi KashiwagiMark C Poznansky
Jul 15, 2011·International Journal of Nanomedicine·Amit KumarZhengrong Cui
Mar 30, 2012·International Journal of Nanomedicine·Sixing YangTuo Jin
Jul 13, 2012·International Journal of Nanomedicine·Jaspreet Singh KochharLifeng Kang
Apr 1, 2011·International Journal of Pharmaceutical Investigation·Ch SarojaShyamala Bhaskaran
Aug 21, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Isabelle SerrCarolin Daniel
Jul 25, 2012·Therapeutic Delivery·Regina Scherliess
Jan 1, 2014·Acta Biomaterialia·Alberto PurwadaAnkur Singh
May 24, 2014·Nature Reviews. Immunology·Bernard MalissenSandrine Henri
Jan 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nak Won KimJi Hoon Jeong
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Jun 12, 2014·Current Treatment Options in Allergy·Gabriela SentiThomas M Kündig
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xinyuan ChenMei X Wu
Jun 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sarah C P Williams
Dec 3, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Qingqing WangChuanbin Wu
Oct 16, 2014·The Journal of Infectious Diseases·Hiromasa OkayasuR Bruce Aylward
May 29, 2014·Pharmaceutical Research·Zhuangzhi ZhuHao Wang
Mar 8, 2011·Bulletin of the World Health Organization·J K HicklingD Kristensen
Jan 29, 2013·Nature Materials·Peter C DeMuthDarrell J Irvine
Nov 19, 2013·Genes & Development·Ian Y WongMehmet Toner
Jul 30, 2011·Drug Delivery and Translational Research·Yeu-Chun Kim, Mark R Prausnitz
Nov 26, 2010·Expert Review of Vaccines·Robert L AtmarWendy A Keitel
Jul 7, 2011·Expert Review of Medical Devices·Martin J GarlandRyan F Donnelly
Oct 17, 2013·Expert Review of Vaccines·Xinyuan ChenMei X Wu
Nov 13, 2015·Expert Opinion on Drug Delivery·N Sanoj RejinoldYeu-Chun Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Qiyun ZhuRichard W Compans
Journal of Controlled Release : Official Journal of the Controlled Release Society
Fu-Shi QuanSang-Moo Kang
Journal of Controlled Release : Official Journal of the Controlled Release Society
Leonard Y Chu, Mark R Prausnitz
© 2021 Meta ULC. All rights reserved