Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial

Dermatology and Therapy
Colin W X TanHong Liang Tey

Abstract

Keloids are a prevalent chronic skin disorder with significant psychosocial morbidity. Intralesional corticosteroid injections are the first-line treatment but are painful and require repeated injections by medical professionals. Dissolving microneedles are a novel method of cutaneous drug delivery that induces minimal/no pain and can be self-administered. The objective of the study was to evaluate the efficacy and safety of triamcinolone-embedded dissolving microneedles in treatment of keloids. This was a single-blind, intra-individual controlled two-phase clinical trial of 8-week duration each. Two keloids per subject were selected for (1) once-daily 2-min application with microneedles for 4 weeks, followed by no treatment for the next 4 weeks, or (2) non-intervention as control. Primary outcome was change in keloid volume as assessed by a high-resolution 3D scanner. There was significant reduction in keloid volume compared with controls after 4 weeks of treatment. This reduction was greater with a higher dosage of triamcinolone used. Once-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alterna...Continue Reading

References

May 1, 1990·The Journal of Burn Care & Rehabilitation·T SullivanD J Courtemanche
Nov 1, 1989·Plastic and Reconstructive Surgery·W B RockwellH P Ehrlich
Dec 1, 1969·Plastic and Reconstructive Surgery·S M Alhady, K Sivanantharajah
Apr 29, 2004·Dermatologic Therapy·A Paul Kelly
Dec 8, 2004·Journal of the American Academy of Dermatology·Siong-See LeeChee-Leok Goh
Mar 11, 2006·Archives of Dermatological Research·Oliver BockUlrich Mrowietz
Mar 16, 2006·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Gan MuneuchiHiroharu H Igawa
May 1, 2012·Plastic and Reconstructive Surgery·Stefania TennaPaolo Persichetti
Jul 12, 2012·Archives of Plastic Surgery·Ahmad Sukari HalimThirumulu Ponnuraj Kannan
Nov 5, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Oliver J Smith, Duncan Angus McGrouther
Apr 1, 2014·Dermatologic Clinics·Sara Ud-Din, Ardeshir Bayat
Apr 29, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
May 29, 2014·Pharmaceutical Research·Zhuangzhi ZhuHao Wang
Oct 1, 2015·Therapeutic Delivery·Chandra Sekhar Kolli
Feb 26, 2016·Pharmaceutical Research·Eneko LarrañetaRyan F Donnelly
Jul 6, 2016·Acta Dermato-venereologica·Eveline BijlardMarc A M Mureau
Jan 10, 2018·Bioengineering & Translational Medicine·Shiying LiuChenjie Xu

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Citations

Nov 25, 2020·Pharmaceutics·Seung-Yeon JeongSong-Yi Kim
Mar 10, 2021·Journal of Pharmaceutical Investigation·Jae Hwan Jung, Sung Giu Jin
Jul 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Minglong ChenChuanbin Wu
Mar 14, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sanjukta DuarahJingyuan Wen
May 29, 2021·Carbohydrate Polymers·Tânia MonizSalette Reis

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