Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C VockMichael Wegmann

Abstract

Increased mucus production is a critical factor impairing lung function in patients suffering from bronchial asthma, the most common chronic inflammatory lung disease worldwide. This study aimed at investigating whether goblet cell (GC) metaplasia and mucus production are differentially regulated in proximal and distal airways. Female Balb/c mice were sensitized to ovalbumin (OVA) and challenged with an OVA-aerosol on two consecutive days for 1 week (acute) or 12 weeks (chronic). Real-time RT-PCR analysis was applied on microdissected airways. In acutely and chronically OVA-challenged mice, GC metaplasia and mucus production were observed in proximal but not in distal airways. In contrast, inflammation reflected by the infiltration of eosinophils and expression of the TH2-type cytokines IL-4 and IL-13 was increased in both proximal and distal airways. Abundance of IL-13Rα1 was lower in distal airways of healthy control mice. Under acute and chronic OVA-exposure, activation of IL-13Rα1-dependent signalling cascade, reflected by Spdef and Foxo3A transcription factors, was attenuated in distal compared to proximal airways. These data indicate that distal airways might be less sensitive to IL-13-induced GC metaplasia and mucus prod...Continue Reading

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Citations

Apr 27, 2016·European Journal of Pharmacology·Zhaoe LiuGang Li
Sep 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G RobertsJ A Woodfolk
Mar 27, 2018·American Journal of Respiratory Cell and Molecular Biology·Gang ChenRichard C Boucher
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dietmar SpenglerMartin F Krause
Aug 8, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T XieGp Li
May 16, 2020·Frontiers in Immunology·Andreas FreyMichael Wegmann

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