Distal angiogenesis: a new concept for lung vascular morphogenesis

American Journal of Physiology. Lung Cellular and Molecular Physiology
Marta Canis PareraRobbert Rottier

Abstract

Although several molecular players have been described that play a role during the early phases of lung development, it is still unknown how the vasculature develops in relation to the airways. Two opposing models describe development of lung vasculature: one suggests that both vasculogenesis and angiogenesis are involved, whereas the second describes vasculogenesis as the primary mechanism. Therefore, we examined the development of the murine pulmonary vasculature through a morphological analysis from the onset of lung development [9.5 days postcoital (dpc)] until the pseudoglandular stage (13.5 dpc). We analyzed fetal lungs of Tie2-LacZ transgenic mice as well as serial sections of wild-type lungs stained with endothelial-specific antibodies (Flk-1, Fli-1, and PECAM-1). Embryos were processed with intact blood circulation to maintain the integrity of the vasculature; hence individual vessels could be identified with accuracy through serial section analysis. Furthermore, circulating primitive erythrocytes, formed exclusively by the blood islands in the yolk sac, are trapped in vessels during fixation, which proves the connection with the embryonic circulation. We report that from the first morphological sign of lung developmen...Continue Reading

References

Sep 1, 1990·The Anatomical Record·P H Burri, M R Tarek
Jan 1, 1995·Annual Review of Cell and Developmental Biology·W Risau, I Flamme
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·T M SchlaegerT N Sato
Apr 17, 1997·Nature·W Risau
May 1, 1997·American Journal of Respiratory Cell and Molecular Biology·D E deMelloL M Reid
Mar 31, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·X ZengJ A Whitsett
Jun 8, 1999·Journal of Pediatric Surgery·K L ColenG K Gittes
Feb 5, 2000·American Journal of Respiratory Cell and Molecular Biology·S K SchachtnerH Scott Baldwin
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S A Gebb, J M Shannon
Jul 13, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·D E deMello, L M Reid
Aug 2, 2000·American Journal of Respiratory Cell and Molecular Biology·S M HallS G Haworth
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A M HealyW V Cardoso
Feb 7, 2001·Circulation Research·T Sato
May 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J TolletM P Sparrow
Aug 10, 2001·Experimental Hematology·J Palis, M C Yoder
Feb 28, 2002·American Journal of Respiratory Cell and Molecular Biology·Susan M HallSheila G Haworth
Mar 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sumiko MaedaHironobu Sasano
Jul 12, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·James M GreenbergAnn L Akeson
Oct 31, 2002·Blood·Kathleen E McGrathJames Palis
Nov 15, 2002·Journal of Anatomy·Alison A Hislop
Nov 30, 2002·Paediatric Respiratory Reviews·Nicola P SmithPaul D Losty
Dec 20, 2002·Mechanisms of Development·Eckhard LammertDouglas Melton
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Kurt R Stenmark, Sarah A Gebb
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Robin N N HanStephen J Lye
Sep 27, 2003·Developmental Biology·Amanda C LaRueChristopher J Drake

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Citations

Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianwen QueBrigid L M Hogan
Oct 20, 2011·Stem Cells and Development·Yasutoshi YamamotoLawrence S Prince
Oct 28, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Margaret A SchwarzHaihua Zheng
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Bernard Thébaud, Steven H Abman
Feb 3, 2012·American Journal of Respiratory Cell and Molecular Biology·Yadi HuangRobbert J Rottier
Oct 16, 2012·American Journal of Respiratory Cell and Molecular Biology·Hyoung-Sook ParkYang-Sook Chun
Oct 2, 2012·The Journal of Clinical Investigation·Caterina TiozzoParviz Minoo
Mar 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Hitoshi IshimotoRobert B Jaffe
Dec 21, 2007·Proceedings of the American Thoracic Society·Kameswara Rao BadriLucia Schuger
Oct 14, 2010·Experimental Lung Research·Carmen Mesas BurgosBjörn Frenckner
May 12, 2016·Histochemistry and Cell Biology·Hyejin SeoSung-Won Cho
Sep 15, 2009·Seminars in Fetal & Neonatal Medicine·T Allen MerrittBruce R Boynton
Jan 3, 2006·Trends in Cardiovascular Medicine·Robin N N Han, Duncan J Stewart
Mar 24, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Csaba Galambos, Daphne E deMello
Mar 25, 2017·Cell·Morgane BelleAlain Chédotal
May 11, 2013·Pulmonary Circulation·Tien Peng, Edward E Morrisey
Dec 30, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Takamasa OnukiMasahide Murasugi
Nov 15, 2018·Physiological Reviews·Jeffrey A WhitsettVladimir V Kalinichenko
Feb 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lin ShanMary E Sunday
Jan 26, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Daphne S MousRobbert J Rottier
May 9, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tiina M AsikainenCarl W White
Sep 22, 2006·Pediatric Research·Cristina Nogueira-SilvaJorge Correia-Pinto
Mar 29, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger
Apr 23, 2011·Expert Review of Respiratory Medicine·Ilona SluiterRobbert J Rottier
Mar 4, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Takaya SuzukiHiroshi Kubo
Apr 12, 2014·The Clinical Respiratory Journal·Yanfen XingXiwen Sun
Nov 27, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Heleen KoolRobbert J Rottier
Jul 4, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Heleen M KoolRobbert J Rottier
Oct 15, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shannon N AckerJason Gien
Oct 21, 2010·Physiological Reviews·Yuansheng Gao, J Usha Raj
Jul 3, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elena CanoRamón Muñoz-Chápuli
Apr 2, 2016·Interactive Cardiovascular and Thoracic Surgery·Takamasa OnukiMasahide Murasugi
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emma L Rawlins
Dec 4, 2012·Oncology Letters·Amalia BirauTeodora Olariu
Mar 20, 2014·Journal of Cellular Biochemistry·Elizabeth A Hines, Xin Sun
May 5, 2017·Annual Review of Biomedical Engineering·Olukemi O AkinteweJoyce Y Wong

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