Distal colon motility in schizophrenic patients

Journal of Clinical Pharmacology
F LechinE Lechin

Abstract

Although the dopaminergic blocking agents (DBA) haloperidol and sulpiride strongly inhibit distal colon motility in most nonpsychotic subjects (83 per cent), this effect was registered in only 10 per cent of the 30 schizophrenic patients investigated in the present study. In these cases, only sulpiride (an "atypical" DBA) displayed distal colon motility inhibition in schizophrenic subjects. When haloperidol (a "classical" DBA) produced any modification (in 23.3 per cent), this was rather in the nature of an increase in motility. All these cases showed low or absent distal colon motility during preinjection periods. the fact that three different types of antinoradrenergic drugs (dihydroergotamine, phentolamine, and clonidine), but not DBA, inhibited distal colon motility in 90 per cent of the schizophrenic subjects suggests the existence of an overactivity of the noradrenergic system at this peripheral level.

References

Dec 1, 1977·The Journal of Pharmacy and Pharmacology·B A McMillen, P A Shore
Jan 1, 1978·The Journal of Pharmacy and Pharmacology·P JennerC D Marsden
Sep 11, 1976·Lancet·T J CrowA Longden
Nov 15, 1977·European Journal of Pharmacology·W HopeM J Rand
May 1, 1977·Journal of Clinical Pharmacology·F LechinF Peña
Jul 1, 1977·Journal of Clinical Pharmacology·F LechinF Peña
Oct 1, 1979·Journal of Clinical Pharmacology·F Lechin, B Van Der Dijs
Mar 1, 1978·The American Journal of Digestive Diseases·G A LanfranchiE M Osset
Jan 1, 1977·Headache·F Lechin, B van der Dijs
Feb 1, 1976·The American Journal of Psychiatry·S H Snyder
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·G A LanfranchiB Menni
Jan 1, 1983·European Journal of Clinical Pharmacology·G A LanfranchiC Brignola
Feb 1, 1983·Journal of Affective Disorders·F LechinL Arocha
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·F LechinM Benaim
Dec 15, 2006·Neuroendocrinology·Fuad Lechin, Bertha van der Dijs
Nov 1, 1980·Journal of Clinical Pharmacology·F LechinL Arocha
Mar 17, 2015·Current Psychiatry Reports·Emily G SeveranceRobert H Yolken
Jul 1, 1989·Medicinal Research Reviews·W J KinnierC Kaiser
Jul 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·J M AllenS R Bloom

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