Distal Colon Motor Dysfunction in Mice with Chronic Kidney Disease: Putative Role of Uremic Toxins

Toxins
Elsa HoibianChristophe O Soulage

Abstract

Although gastrointestinal complications are a common feature of patients with chronic kidney disease (CKD), the impact of uremia on bowel motility remains poorly understood. The present study was, therefore, designed to investigate the impact of uremia on gut motility. Kidney failure was induced in mice by chemical nephrectomy using an adenine diet (0.25% w/w). Gastrointestinal transit time and colon motility were explored in vivo and ex vivo. Colons from control mice were incubated with uremic plasma or uremic toxins (urea, indoxyl-sulfate or p-cresyl-sulfate) at concentrations encountered in patients with end-stage renal disease. Mice fed an adenine diet for 3 weeks exhibited a 3-fold increase in plasma urea (p < 0.001) evidencing kidney failure. The median gastrointestinal transit time was doubled (1.8-fold, p < 0.001) while a reduction in colonic propulsive motility was observed in CKD mice (3-fold, p < 0.001). Colon from CKD mice exhibited an abnormal pattern of contraction associated with a blunted maximal force of contraction. Control colons incubated with plasma from hemodialysis patients exhibited a blunted level of maximal contraction (p < 0.01). Incubation with urea did not elicit any difference but incubation with i...Continue Reading

References

Jun 1, 1991·Scandinavian Journal of Gastroenterology·J HegbrantR Ekman
Jan 1, 1986·Nephron·T YokozawaF Koizumi
Dec 1, 1984·American Journal of Surgery·K R SirinekB A Levine
Oct 1, 1982·Journal of Nutritional Science and Vitaminology·T YokozawaT Okada
Jul 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K ShimaN Yanaihara
Dec 1, 1980·Gut·I L TaylorG J Dockray
Feb 1, 1993·Digestive Diseases and Sciences·J Y Kang
Jan 1, 1996·Nephron·I DoğanE Hasanoğlu
Dec 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A M Ravelli
May 1, 1997·Digestive Diseases and Sciences·X LinJ D Chen
Feb 12, 1998·The American Journal of Physiology·J WenS F Phillips
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H P LefebvreP L Toutain
Oct 9, 2002·Circulation·Martin HausbergKarl Heinz Rahn
Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thiriloganathan Mathialahan, Geoffrey I Sandle
Apr 5, 2003·Kidney International·Raymond VanholderUNKNOWN European Uremic Toxin Work Group (EUTox)
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ming-Ju WuMing-Jer Tang
Apr 14, 2006·Kidney International·H YamamotoE Kusano
May 22, 2007·The American Journal of Gastroenterology·Alicia E CanoDouglas Maxwell
Jun 7, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Raymond VanholderUNKNOWN European Uremic Toxin Work Group (EUTox)
Aug 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerald CohenUNKNOWN European Uremic Toxin Work Group (EUTox)
Dec 14, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hiroshi AdachiTakashi Joh
Feb 22, 2008·Journal of the American Society of Nephrology : JASN·Raymond VanholderUNKNOWN European Uremic Toxin Work Group
Jan 6, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Gulinuer MuteliefuToshimitsu Niwa
Jan 24, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gulinuer MuteliefuToshimitsu Niwa
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
Dec 1, 2009·Kidney International. Supplement·Pieter EvenepoelKristin Verbeke
Jul 26, 2011·Journal of the American Society of Nephrology : JASN·Pavel A AronovTimothy W Meyer
Dec 2, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D VaziriVeedamali S Subramanian
May 26, 2012·Journal of the American Society of Nephrology : JASN·Flore DurantonUNKNOWN European Uremic Toxin Work Group
Jan 1, 2013·Journal of the American Society of Nephrology : JASN·Laetitia KoppeChristophe O Soulage
Mar 6, 2013·Seminars in Dialysis·Ruben PoesenPieter Evenepoel
Dec 20, 2014·Journal of the American Society of Nephrology : JASN·Eikan MishimaTakaaki Abe
Feb 14, 2015·Physiological Reports·José Ronaldo Vasconcelos da GraçaArmenio Aguiar Dos Santos
Feb 19, 2015·Pharmacology Research & Perspectives·Hiroshi WatanabeToru Maruyama
Mar 31, 2015·Clinical Kidney Journal·Raymond Vanholder, Griet Glorieux
Jul 5, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Hsiang Chou, Tun-Jun Tsai
Sep 21, 2016·Cellular and Molecular Gastroenterology and Hepatology·Michael Camilleri, David R Linden
Nov 23, 2016·Clinical Science·Wei Ling Lau, Nosratola D Vaziri
Jun 2, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gao-Jue WuJiande D Z Chen

❮ Previous
Next ❯

Citations

Jun 28, 2019·Nature Reviews. Nephrology·Björn MeijersHans-Joachim Anders
Dec 2, 2020·Microorganisms·Ryota IkeeSawako Fukazawa
Feb 12, 2020·KI Reports·Keiichi SumidaCsaba P Kovesdy
Feb 6, 2021·Mucosal Immunology·Bernadette Jones-FreemanMalcolm R Starkey
Nov 19, 2020·Journal of Clinical Pharmacology·Paul R V MalikAndrea N Edginton
May 21, 2021·Journal of Feline Medicine and Surgery·Sarah E JonesAdam J Rudinsky
Nov 16, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Tsukasa NakamuraMikiko Yoshikawa
Dec 11, 2021·The Science of the Total Environment·Daniel J RawleAndreas Suhrbier

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
Dissection

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Masafumi Fukagawa, Yuzo Watanabe
Ryōikibetsu shōkōgun shirīzu
S Suzuki
© 2022 Meta ULC. All rights reserved