Distal tibial mononeuropathy in diabetic and nondiabetic rats reared on wire cages: an experimental entrapment neuropathy

Brain Research
D W ZochodneR J Riopelle

Abstract

Using electrophysiological recordings, we studied a distal tibial mononeuropathy that involves the hind foot of rats reared in cages with wire grid flooring. In an initial set of experiments, serial sciatic-tibial motor conduction recordings were made in smaller or larger rats reared in cages with wire grid or sawdust flooring. Electrophysiological features of the neuropathy were loss in the amplitude of the distal tibial nerve M potential recorded over hind limb foot muscles, temporal dispersion of the potential, often into multiple peaks, and a prolonged distal latency of the response. The changes in M amplitude were more apparent in larger rats with a greater body weight. In a second series of experiments we studied sciatic-tibial conduction over 16 weeks in nondiabetic rats and rats rendered diabetic with streptozotocin raised and wire grid or plastic flooring. Tibial mononeuropathy developed in both wire grid-reared groups, but there was evidence that it appeared earlier in diabetic rats. Electrophysiological changes of distal mononeuropathy also obscured the expected slowing of sciatic-tibial motor conduction velocity from diabetics. Tibial mononeuropathy in rats reared on wire grid flooring may be a useful animal model o...Continue Reading

References

Dec 11, 1992·Brain Research·D W Zochodne, L T Ho
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J D SchmelzerP A Low
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P J DyckJ L Karnes

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Citations

Jul 20, 2002·Regional Anesthesia and Pain Medicine·Quinn Hogan
Sep 5, 2009·Journal of Clinical Neuromuscular Disease·Katalin Scherer
Jun 5, 2004·Neuroimaging Clinics of North America·Elisabeth J Rushing, John-Paul Bouffard
Apr 29, 1999·Brain Pathology·D W Zochodne
Sep 27, 2000·Journal of Neuropathology and Experimental Neurology·D W ZochodneM Lauritzen

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