Distal to proximal development of peripheral nerves requires the expression of neurofilament heavy.

Neuroscience
H ShenMichael L Garcia

Abstract

At the initiation of radial growth, neurofilaments are likely to consist primarily of neurofilament light and medium as neurofilament heavy expression is developmentally delayed. To better understand the role of neurofilament heavy in structuring axons, axonal diameter and neurofilament organization were measured in proximal and distal segments of the sciatic nerve and along the entire length of the phrenic nerve. Deletion of neurofilament heavy reduced axonal diameters and neurofilament number in proximal nerve segments. However, neurofilament spacing was greater in proximal versus distal phrenic nerve segments. Taken together, these results suggest that loss of neurofilament heavy reduces radial growth in proximal axonal segments by reducing the accumulation of neurofilaments. As neurofilament heavy expression is developmentally delayed, these results suggest that without neurofilament heavy, the neurofilament network is established in a distal to proximal gradient perhaps to allow distal axonal segments to develop prior to proximal segments.

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Citations

May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Devin M BarryMichael L Garcia
Jan 20, 2011·Biophysical Journal·Matthew O'Toole, Kyle E Miller
Jan 31, 2015·Current Opinion in Cell Biology·Adi Laser-AzoguiRoy Beck
Jul 25, 2015·PloS One·Aidong YuanRalph A Nixon
Jan 11, 2017·Muscle & Nerve·Maria R JonesMichael L Garcia
Oct 8, 2017·Journal of Biomedical Materials Research. Part a·Junyi ZhuJian Wang

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