Distant Metastases in Patients with Carcinoma of the Major Salivary Glands

Annals of Surgical Oncology
Safina AliIan Ganly

Abstract

This study aimed to show the incidence of distant metastases (DM) in salivary gland cancer as well as the types of histology most commonly associated with it and to identify factors predictive of DM. The study identified 301 patients who underwent surgery for cancer of the major salivary glands at Memorial Sloan-Kettering Cancer center between 1985 and 2009. Clinical, tumor, and treatment characteristics were recorded. Tumors were categorized as low-, intermediate-, and high-risk pathology based on histologic subtype and grade. Factors predictive of distant recurrence-free probability (DRFP) were determined by uni- and multivariable analyses. The primary tumor was parotid in 266 patients (88 %), and 96 tumors (32 %) were clinical T3/T4. For 57 patients (18.9 %), DM developed with a 5-year DRFP of 72.7 %. The most common site of metastasis was the lung (50 %). The clinical predictors were male gender, cT4 stage, cN+ stage, and clinical overall stage. The multivariable analysis of clinical variables showed male gender (p = 0.018), cT4 stage (p < 0.001), and cN+ stage (p = 0.004) to be significant. The pathologic predictors were high-risk and high-grade pathology, vascular invasion, perineural invasion, positive margins, pT4 stage...Continue Reading

References

Jan 1, 1987·Seminars in Surgical Oncology·G Y Yu, D Q Ma
Jan 7, 1998·Clinical Otolaryngology and Allied Sciences·A S JonesT R Helliwell
Nov 28, 1997·American Journal of Surgery·R H Spiro
Jun 22, 1999·British Journal of Cancer·A G RenehanM McGurk
Jun 16, 2001·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·P J Bradley
Aug 19, 2003·Seminars in Surgical Oncology·Leslie H Sobin
Dec 10, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A Sefik HosalEugene N Myers
Apr 13, 2006·Acta Oto-laryngologica·Ilona SchwentnerGeorg Sprinzl
May 5, 2009·The British Journal of Oral & Maxillofacial Surgery·Paul M Speight, A William Barrett
Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Nov 29, 2013·Archives of Pathology & Laboratory Medicine·Ronghui XiaJiang Li

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Citations

Oct 31, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Boban M ErovicDavid P Goldstein
Aug 23, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marlen HaderleinAbbas Agaimy
Jul 5, 2019·Head & Neck·Luca Giovanni LocatelloOreste Gallo
May 23, 2019·BMC Cancer·Qigen FangXu Zhang
Feb 27, 2019·Journal of Cancer Research and Clinical Oncology·Won Ki ChoSang Yoon Kim
Jun 6, 2018·Frontiers in Surgery·Jovanna ThielkerOrlando Guntinas-Lichius
Sep 30, 2017·Head & Neck·Karoliina HirvonenAntti A Mäkitie
Jul 28, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Claudia ScherlHeinrich Iro
Jan 25, 2020·World Journal of Clinical Oncology·Syed Ahmed AliMatthew E Spector
Aug 31, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sakurako AsaiTohru Kurabayashi
Feb 14, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wei WangJie Zhang
Jul 12, 2018·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Mateusz SzewczykWojciech Golusiński
Dec 12, 2018·Oral Oncology·Kristy A WarnerJacques E Nör
Aug 27, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Viola FreitagMarlen Haderlein
Nov 17, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Liliya BenchetritHeather A Edwards
Dec 3, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Martin HansonIan Ganly

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