Distilled Water Lavage During Surgery Improves Long-Term Outcomes of Patients with Ruptured Hepatocellular Carcinoma

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Shao-jun ZhouZhi-yong Huang

Abstract

Rupture of hepatocellular carcinoma (HCC) releases tumor cells and furthers peritoneal metastasis. The present study investigated the killing effects of distilled water (DW) on HCC cells and the clinical outcomes of patients undergoing liver resection with DW lavage for spontaneously ruptured HCC. Human HCC cells (BEL-7402, SMMC7721) were treated with DW, the morphological changes observed, and cell viability measured. DW-treated HCC cells were also injected intraperitoneally into nude mice, and the formation of tumor nodules and overall survival (OS) measured. The clinicopathological data of 141 consecutive patients undergoing liver resection for spontaneously ruptured HCC during 1998-2011 were retrospectively reviewed. Fifteen minutes of DW exposure caused complete cell lysis of HCC cells in vitro and completely prevented tumor formation and prolonged survival time in nude mice. Among the 141 patients, the 1-, 3-, and 5-year disease-free survival (DFS) and OS rates in patients administered DW lavage during surgery were 68.9, 24.6, and 6.6%, respectively, and 95.1, 65.1, and 40%, respectively, which were significantly higher than those in patients who did not (P < 0.05). DW lavage was an independent predictor of recurrence (od...Continue Reading

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Citations

Nov 9, 2017·Journal of Surgical Oncology·Demetrios MorisTimothy M Pawlik
Mar 15, 2018·European Journal of Gastroenterology & Hepatology·Gaëtan-Romain JoliatNermin Halkic
Aug 23, 2019·International Journal of Oncology·Atsushi ShiozakiEigo Otsuji
Oct 18, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wei ZhangXiao-Ping Chen
Feb 12, 2017·The Journal of Physiological Sciences : JPS·Atsushi ShiozakiEigo Otsuji

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