Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm

Journal of the Neurological Sciences
Seiya TanakaGen Sobue

Abstract

Laryngospasm is a sudden onset of transient respiratory difficulty that is perceived as life-threatening by patients with spinal and bulbar muscular atrophy (SBMA). The purpose of the study was to analyze the voice characteristics of SBMA patients with laryngospasm using acoustic voice analysis. Acoustic measurements were obtained from 39 consecutive Japanese patients with genetically confirmed SBMA. A comparison was made between the acoustic voice profiles of 16 patients with laryngospasm and 23 patients without laryngospasm within 6 months before the evaluation. Computerized acoustic analysis was performed for a prolonged vowel (/a:/) using the Multi-Dimensional Voice Program (MDVP). SBMA patients with laryngospasm had smaller fluctuations of vocal fold vibration and the turbulent noise component, indicating stronger vocal fold closure than in those without laryngospasm. Receiver operating characteristic curve analysis showed that the noise-to-harmonic ratio, which globally measures the noise components of voice, is the most useful acoustic parameter to distinguish laryngospasm (area under the curve = 0.767, p = 0.007). The smaller noise component in patients with laryngospasm suggests that the vocal folds of these patients a...Continue Reading

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Citations

Oct 21, 2015·Journal of Molecular Neuroscience : MN·Josef Finsterer, Gianni Soraru
Sep 7, 2017·Muscle & Nerve·Robert D GuberChristopher Grunseich
Mar 28, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Querin GiorgiaGianni Sorarù

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